Natriuretic Peptide, C-Type. C-Type Natriuretic Peptide-22 . C-Type Natriuretic Peptide-53 . CNP-22 . CNP-53 . C Type Natriuretic Peptide . C Type Natriuretic Peptide 22 . C Type Natriuretic Peptide 53 . Natriuretic Peptide, C Type . Natriuretic Peptide-22, C-Type . Natriuretic Peptide-53, C-Type . Peptide, C-Type Natriuretic . Peptide-22, C-Type Natriuretic . Peptide-53, C-Type Natriuretic . C-Type Natriuretic Peptide . A PEPTIDE of 22 amino acids, derived mainly from cells of VASCULAR ENDOTHELIUM. It is also found in the BRAIN, major endocrine glands, and other tissues. It shares structural homology with ATRIAL NATRIURETIC FACTOR. It has vasorelaxant activity thus is important in the regulation of vascular tone and blood flow. Several high molecular weight forms containing the 22 amino acids have been identified. . 1.00
Calcitonin Gene-Related Peptide. Calcitonin Gene-Related Peptide I . Calcitonin Gene-Related Peptide II . alpha-CGRP . beta-CGRP . Calcitonin Gene Related Peptide . Calcitonin Gene Related Peptide I . Calcitonin Gene Related Peptide II . Gene-Related Peptide, Calcitonin . Peptide, Calcitonin Gene-Related . alpha CGRP . beta CGRP . A 37-amino acid peptide derived from the calcitonin gene. It occurs as a result of alternative processing of mRNA from the calcitonin gene. The neuropeptide is widely distributed in the brain, gut, perivascular nerves, and other tissue. The peptide produces multiple biological effects and has both circulatory and neurotransmitter modes of action. In particular, it is a potent endogenous vasodilator. . 0.38
Receptors, Vascular Endothelial Growth Factor. Endothelial Growth Factor Receptor . Receptor, Endothelial Growth Factors . Receptor, Vascular Endothelial Cell Growth Factor . Receptor, Vascular Permeability Factor . VEGF Receptor . VEGF Receptors . VPF Receptor . Vascular Endothelial Cell Growth Factor Receptor . Vascular Endothelial Growth Factor Receptor . Vascular Permeability Factor Receptor . Receptors, VEGF . A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular IG-LIKE DOMAINS which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels. . 0.35
Cyclic Nucleotide Phosphodiesterases, Type 5. PDE5 Phosphodiesterases . Phosphodiesterase 5 . Phosphodiesterase 5A . Phosphodiesterase 5A, cGMP-Specific . Phosphodiesterase Type 5 . Phosphodiesterase Type V . Phosphodiesterase V . Phosphodiesterase-5 . cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase . Phosphodiesterase 5A, cGMP Specific . Phosphodiesterases, PDE5 . Type 5, Phosphodiesterase . Type V, Phosphodiesterase . cGMP-Specific Phosphodiesterase 5A . A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction. . 0.35
Corticotropin-Like Intermediate Lobe Peptide. ACTH(18-39) . ACTHalpha(18-39), Ser(31)- . ACTHalpha(18-39), Serine(31)- . CLILP . CLIP (ACTH 18-39) . Corticotropin Like Intermediate Lobe Peptide . A peptide derived from the cleavage of ADRENOCORTICOTROPIC HORMONE, found primarily in the INTERMEDIATE LOBE OF PITUITARY but also in the ARCUATE NUCLEUS of basal HYPOTHALAMUS. Its sequence is identical to the C-terminal 22-amino acids of ACTH or ACTH 18-39. . 0.34
Peptide PHI. Human PHI . PHM Neuropeptide . PHM-27 . Peptide HI . Peptide Histidine Methionine . Peptide PHI-27 . Peptide-Histidine-Isoleucinamide . Porcine Intestinal Heptacosapeptide . Pro-Vasoactive Intestinal Peptide . Heptacosapeptide, Porcine Intestinal . Histidine Methionine, Peptide . Histidine-Isoleucine, Peptide . Intestinal Heptacosapeptide, Porcine . Intestinal Peptide, Pro-Vasoactive . Methionine, Peptide Histidine . Neuropeptide, PHM . PHI, Human . PHM, Peptide . Peptide Histidine Isoleucinamide . Peptide Histidine Isoleucine . Peptide PHI 27 . Peptide, PHI . Peptide, Pro-Vasoactive Intestinal . Pro Vasoactive Intestinal Peptide . Neuropeptide PHI 27 . Peptide Histidine-Isoleucine . Peptide PHM . PHI Peptide . A 27-amino acid peptide with histidine at the N-terminal and isoleucine amide at the C-terminal. The exact amino acid composition of the peptide is species dependent. The peptide is secreted in the intestine, but is found in the nervous system, many organs, and in the majority of peripheral tissues. It has a wide range of biological actions, affecting the cardiovascular, gastrointestinal, respiratory, and central nervous systems. . 0.33
Vascular Endothelial Growth Factor A. GD-VEGF . Glioma-Derived Vascular Endothelial Cell Growth Factor . VEGF 25902 . VEGF-A . Vascular Permeability Factor . Vasculotropin . Glioma Derived Vascular Endothelial Cell Growth Factor . Permeability Factor, Vascular . Vascular Endothelial Growth Factor . Vascular Endothelial Growth Factor-A . The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced. . 0.33
Natriuretic Peptide, Brain. B-Type Natriuretic Peptide . BNP Gene Product . BNP-32 . Brain Natriuretic Peptide-32 . Natrecor . Natriuretic Factor-32 . Natriuretic Peptide Type-B . Type-B Natriuretic Peptide . Ventricular Natriuretic Peptide, B-type . BNP 32 . Brain Natriuretic Peptide 32 . Natriuretic Factor 32 . Natriuretic Peptide Type B . Natriuretic Peptide, B-Type . Natriuretic Peptide, Type-B . Natriuretic Peptide-32, Brain . Peptide, Brain Natriuretic . Peptide-32, Brain Natriuretic . Type B Natriuretic Peptide . Ventricular Natriuretic Peptide, B type . Brain Natriuretic Peptide . Nesiritide . A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS. . 0.33
Leukotriene C4. Leukotriene C . Leukotriene C-1 . Leukotriene C-4 . Leukotriene C1 . Leukotrienes C . Leukotriene C 1 . Leukotriene C 4 . LTC4 19440 . The conjugation product of LEUKOTRIENE A4 and glutathione. It is the major arachidonic acid metabolite in macrophages and human mast cells as well as in antigen-sensitized lung tissue. It stimulates mucus secretion in the lung, and produces contractions of nonvascular and some VASCULAR SMOOTH MUSCLE. (From Dictionary of Prostaglandins and Related Compounds, 1990) . 0.32
