Phenobarbital. Gardenal . Hysteps . Luminal . Phenobarbital Sodium . Phenobarbital, Monosodium Salt . Phenylethylbarbituric Acid . Acid, Phenylethylbarbituric . Monosodium Salt Phenobarbital . Sodium, Phenobarbital . Phenemal . Phenobarbitone . Phenylbarbital . A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. . 1.00
Receptors, Amino Acid. Receptor, Amino Acid . Receptors, Amino Acids . Amino Acid Receptor . Amino Acids Receptors . Amino Acid Receptors . Cell surface proteins that bind amino acids and trigger changes which influence the behavior of cells. Glutamate receptors are the most common receptors for fast excitatory synaptic transmission in the vertebrate central nervous system, and GAMMA-AMINOBUTYRIC ACID and glycine receptors are the most common receptors for fast inhibition. . 0.41
Picrotoxin. A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. . 0.40
Receptors, GABA. GABA Receptor . gamma-Aminobutyric Acid Receptor . Receptor, GABA . Receptor, gamma-Aminobutyric Acid . Receptors, gamma Aminobutyric Acid . gamma Aminobutyric Acid Receptor . gamma Aminobutyric Acid Receptors . gamma-Aminobutyric Acid Receptors . GABA Receptors . Receptors, gamma-Aminobutyric Acid . Cell-surface proteins that bind GAMMA-AMINOBUTYRIC ACID with high affinity and trigger changes that influence the behavior of cells. GABA-A receptors control chloride channels formed by the receptor complex itself. They are blocked by bicuculline and usually have modulatory sites sensitive to benzodiazepines and barbiturates. GABA-B receptors act through G-proteins on several effector systems, are insensitive to bicuculline, and have a high affinity for L-baclofen. . 0.40