serw-MX  [xml]  
 


    
 DeCS Categories

D06 Hormones, Hormone Substitutes, and Hormone Antagonists .
D06.472 Hormones .
D06.472.699 Peptide Hormones .
D06.472.699.094 Angiotensins .
D06.472.699.094.075 Angiotensin I .
D06.472.699.094.078 Angiotensin II .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.277 Hydrolases .
D08.811.277.656 Peptide Hydrolases .
D08.811.277.656.350 Exopeptidases .
D08.811.277.656.350.100 Aminopeptidases .
D08.811.277.656.350.100.373 Glutamyl Aminopeptidase .
D08.811.277.656.350.555 Metalloexopeptidases .
D08.811.277.656.350.555.600 Glutamyl Aminopeptidase .
D08.811.277.656.675 Metalloproteases .
D08.811.277.656.675.555 Metalloexopeptidases .
D08.811.277.656.675.555.600 Glutamyl Aminopeptidase .
D12 Amino Acids, Peptides, and Proteins .
D12.125 Amino Acids .
D12.125.072 Amino Acids, Cyclic .
D12.125.072.401 Imino Acids .
D12.125.072.401.623 Proline .
D12.125.072.401.623.270 Captopril .
D12.644 Peptides .
D12.644.400 Neuropeptides .
D12.644.400.070 Angiotensins .
D12.644.400.070.075 Angiotensin I .
D12.644.400.070.078 Angiotensin II .
D12.644.456 Oligopeptides .
D12.644.456.073 Angiotensins .
D12.644.456.073.021 Angiotensin I .
D12.644.456.073.041 Angiotensin II .
D12.644.548 Peptide Hormones .
D12.644.548.058 Angiotensins .
D12.644.548.058.075 Angiotensin I .
D12.644.548.058.078 Angiotensin II .
D12.776 Proteins .
D12.776.631 Nerve Tissue Proteins .
D12.776.631.650 Neuropeptides .
D12.776.631.650.070 Angiotensins .
D12.776.631.650.070.075 Angiotensin I .
D12.776.631.650.070.078 Angiotensin II .
D23 Biological Factors .
D23.469 Inflammation Mediators .
D23.469.050 Autacoids .
D23.469.050.050 Angiotensins .
D23.469.050.050.025 Angiotensin I .
D23.469.050.050.050 Angiotensin II .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.389 Enzyme Inhibitors .
D27.505.519.389.745 Protease Inhibitors .
D27.505.519.389.745.085 Angiotensin-Converting Enzyme Inhibitors .
D27.505.519.389.745.085.500 Vasopeptidase Inhibitors .
G03 Metabolism .
G03.820 Renin-Angiotensin System .
G09 Circulatory and Respiratory Physiological Phenomena .
G09.330 Cardiovascular Physiological Phenomena .
G09.330.380 Hemodynamics .
G09.330.380.813 Renin-Angiotensin System .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Captopril .
(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline .
Capoten .
Lopirin .
SQ-14,225 .
SQ-14,534 .
SQ-14225 .
SQ-14534 .
SQ 14,225 .
SQ 14,534 .
SQ 14225 .
SQ 14534 .
SQ14,225 .
SQ14,534 .
SQ14225 .
SQ14534 .
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin. .
1.00
2649825
 
Angiotensin I .
A decapeptide that is cleaved from precursor angiotensinogen by RENIN. Angiotensin I has limited biological activity. It is converted to angiotensin II, a potent vasoconstrictor, after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. .
0.58
443693
 
Angiotensin II .
5-L-Isoleucine Angiotensin II .
ANG-(1-8)Octapeptide .
Angiotensin II, Isoleucine(5)- .
Angiotensin II, Valine(5)- .
Angiotensin-(1-8) Octapeptide .
Isoleucine(5)-Angiotensin .
Isoleucyl(5)-Angiotensin II .
Valyl(5)-Angiotensin II .
5 L Isoleucine Angiotensin II .
Angiotensin II, 5-L-Isoleucine .
Angiotensin II, Ile(5)- .
Angiotensin II, Val(5)- .
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS. .
0.58
24234599
 
Angiotensins .
Angiotensin .
Oligopeptides which are important in the regulation of blood pressure (VASOCONSTRICTION) and fluid homeostasis via the RENIN-ANGIOTENSIN SYSTEM. These include angiotensins derived naturally from precursor ANGIOTENSINOGEN, and those synthesized. .
0.57
641953
 
Renin-Angiotensin System .
Renin Angiotensin Aldosterone System .
Renin Angiotensin System .
System, Renin-Angiotensin .
System, Renin-Angiotensin-Aldosterone .
Renin-Angiotensin-Aldosterone System .
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM. .
0.56
31015832
 
Glutamyl Aminopeptidase .
Aminopeptidase A .
Angiotensinase A .
Aspartate Aminopeptidase .
Aspartyl Aminopeptidase .
Aminopeptidase, Aspartate .
Aminopeptidase, Aspartyl .
Aminopeptidase, Glutamyl .
A ZINC-dependent membrane-bound aminopeptidase that catalyzes the N-terminal peptide cleavage of GLUTAMATE (and to a lesser extent ASPARTATE). The enzyme appears to play a role in the catabolic pathway of the RENIN-ANGIOTENSIN SYSTEM. .
0.55
0430
 
Vasopeptidase Inhibitors .
ACE-NEP Inhibitors .
NEP-ACE Inhibitors .
ACE NEP Inhibitors .
NEP ACE Inhibitors .
A class of cardiovascular drugs indicated for hypertension and congestive heart failure that simultaneously inhibit both NEUTRAL ENDOPEPTIDASE and ANGIOTENSIN CONVERTING ENZYME. They increase the availability of NATRIURETIC PEPTIDES and BRADYKININ and inhibit production of ANGIOTENSIN II. .
0.53
00