Baculoviral IAP Repeat-Containing 3 Protein. Apoptosis Inhibitor 2 . BIRC3 Protein . Baculoviral IAP Repeat Containing Protein 3 . Cellular Inhibitor of Apoptosis-2 . Hiap-1 Protein . IAP1 Protein . Inhibitor of Apoptosis 1 Protein . Inhibitor of Apoptosis Protein 1 . c-IAP2 Protein . cIAP2 Protein . Apoptosis-2 Cellular Inhibitor . Baculoviral IAP Repeat Containing 3 Protein . Cellular Inhibitor of Apoptosis 2 . Hiap 1 Protein . Inhibitor 2, Apoptosis . A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells. . 1.00
Carbonic Anhydrase IX. CAIX Protein . Carbonic Anhydrase 9 . A carbonic anhydrase and transmembrane protein that consists of an N-terminal PROTEOGLYCAN-like domain, a catalytic region, a single-pass transmembrane domain, and a short intracellular tail. It functions as a dimer and is expressed primarily by cells of the GASTROINTESTINAL TRACT; BILE DUCT EPITHELIUM; and GALL BLADDER. It is expressed at high levels in many solid tumors, especially CLEAR CELL RENAL CARCINOMA, in response to CELL HYPOXIA. . 0.41
Interferon-Induced Helicase, IFIH1. CADM-140 Autoantigen . Helicard . IFIH1 Protein . Interferon Induced with Helicase C Domain 1 . Interferon-Induced Helicase C Domain-Containing Protein 1 . Melanoma Differentiation-Associated Protein 5 . Autoantigen, CADM-140 . CADM 140 Autoantigen . Helicase, IFIH1 Interferon-Induced . IFIH1 Interferon-Induced Helicase . Interferon Induced Helicase C Domain Containing Protein 1 . Interferon Induced Helicase, IFIH1 . Melanoma Differentiation Associated Protein 5 . A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS. . 0.40
Tripartite Motif-Containing Protein 28. TRIM28 Protein . Tripartite Motif Containing Protein 28 . A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53. . 0.40
Pyrin. MEFV Protein . Marenostrin . Mediterranean Fever Protein . TRIM20 Protein . A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. . 0.39
WW Domain-Containing Oxidoreductase. WWOX Protein . Oxidoreductase, WW Domain-Containing . WW Domain Containing Oxidoreductase . A short chain oxidoreductase that contains two N-terminal WW DOMAINS and functions as a tumor suppressor and in APOPTOSIS. It is also required for bone development. . 0.37
Low Density Lipoprotein Receptor-Related Protein-2. Antigen GP 330, Nephritis . GP330 Antigen . Glycoprotein 330 . Heyman's Nephritis Antigen GP330 . Heymann Nephritis Antigen GP330 . LRP-2 Receptor . Nephritis Antigen (GP330) . Renal Glycoprotein GP330 . GP330, Renal Glycoprotein . Glycoprotein GP330, Renal . LDL Receptor Related Protein 2 . LRP 2 Receptor . Low Density Lipoprotein Receptor Related Protein 2 . LDL-Receptor Related Protein 2 . Low-Density Lipoprotein Receptor-Related Protein-2 . Megalin . An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS. . 0.37
Mitogen-Activated Protein Kinase 13. MAPK13 Mitogen-Activated Protein Kinase . SAPK4 . Stress-Activated Protein Kinase 4 . p38delta . p38delta MAP Kinase . Kinase, p38delta MAP . MAP Kinase, p38delta . MAPK13 Mitogen Activated Protein Kinase . Mitogen Activated Protein Kinase 13 . Stress Activated Protein Kinase 4 . A 38-kDa mitogen-activated protein kinase found expressed at high levels in LUNG; KIDNEY; TESTIS; PANCREAS; and SMALL INTESTINE. It may play a role in regulating functions such as CELL DIFFERENTIATION and APOPTOSIS of EPITHELIAL CELLS. . 0.37
AC133 Antigen. AC133-1 Antigen . AC133-2 Antigen . AC141 Antigen . CD133 Antigen . Fudenine . PROML1 . Prominin . Prominin-1 . Prominin-Like PROML1 . AC133 1 Antigen . AC133 2 Antigen . Antigen, AC133 . Antigen, AC133-1 . Antigen, AC133-2 . Antigen, AC141 . Antigen, CD133 . Prominin 1 . Prominin Like PROML1 . A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism. . 0.37
Sequestosome-1 Protein. EBI3-Associated Protein of 60 KDa . EBIAP Protein . Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda . Ubiquitin-Binding Protein p62 . EBI3 Associated Protein of 60 KDa . Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda . Sequestosome 1 Protein . Ubiquitin Binding Protein p62 . A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS. . 0.37
