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 DeCS Categories

C12 Male Urogenital Diseases .
C12.777 Urologic Diseases .
C12.777.419 Kidney Diseases .
C12.777.419.815 Renal Tubular Transport, Inborn Errors .
C12.777.419.815.491 Gitelman Syndrome .
C13 Female Urogenital Diseases and Pregnancy Complications .
C13.351 Female Urogenital Diseases .
C13.351.968 Urologic Diseases .
C13.351.968.419 Kidney Diseases .
C13.351.968.419.815 Renal Tubular Transport, Inborn Errors .
C13.351.968.419.815.491 Gitelman Syndrome .
C16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities .
C16.320 Genetic Diseases, Inborn .
C16.320.565 Metabolism, Inborn Errors .
C16.320.565.861 Renal Tubular Transport, Inborn Errors .
C16.320.565.861.491 Gitelman Syndrome .
C18 Nutritional and Metabolic Diseases .
C18.452 Metabolic Diseases .
C18.452.648 Metabolism, Inborn Errors .
C18.452.648.861 Renal Tubular Transport, Inborn Errors .
C18.452.648.861.491 Gitelman Syndrome .
D02 Organic Chemicals .
D02.065 Amides .
D02.065.884 Sulfonamides .
D02.065.884.575 Mefruside .
D02.241 Carboxylic Acids .
D02.241.081 Acids, Acyclic .
D02.241.081.018 Acetates .
D02.241.081.018.386 Glycolates .
D02.241.081.018.386.682 Phenoxyacetates .
D02.241.081.018.386.682.300 Ethacrynic Acid .
D02.241.511 Hydroxy Acids .
D02.241.511.316 Glycolates .
D02.241.511.316.682 Phenoxyacetates .
D02.241.511.316.682.200 Ethacrynic Acid .
D02.886 Sulfur Compounds .
D02.886.590 Sulfones .
D02.886.590.700 Sulfonamides .
D02.886.590.700.135 Benzothiadiazines .
D02.886.590.700.135.261 Chlorothiazide .
D02.886.590.700.135.261.476 Hydrochlorothiazide .
D02.886.590.700.575 Mefruside .
D02.886.655 Thiazides .
D02.886.655.500 Benzothiadiazines .
D02.886.655.500.261 Chlorothiazide .
D02.886.655.500.261.476 Hydrochlorothiazide .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.679 Pyrazines .
D03.383.679.149 Amiloride .
D03.633 Heterocyclic Compounds, Fused-Ring .
D03.633.100 Heterocyclic Compounds, 2-Ring .
D03.633.100.174 Benzothiadiazines .
D03.633.100.174.261 Chlorothiazide .
D03.633.100.174.261.476 Hydrochlorothiazide .
D04 Polycyclic Compounds .
D04.210 Fused-Ring Compounds .
D04.210.500 Steroids .
D04.210.500.745 Pregnanes .
D04.210.500.745.745 Pregnenes .
D04.210.500.745.745.654 Pregnenediones .
D04.210.500.745.745.654.062 Aldosterone .
D06 Hormones, Hormone Substitutes, and Hormone Antagonists .
D06.472 Hormones .
D06.472.040 Adrenal Cortex Hormones .
D06.472.040.585 Hydroxycorticosteroids .
D06.472.040.585.353 11-Hydroxycorticosteroids .
D06.472.040.585.353.118 Aldosterone .
D12 Amino Acids, Peptides, and Proteins .
D12.644 Peptides .
D12.644.456 Oligopeptides .
D12.644.456.345 Dipeptides .
D12.644.456.345.360 Enalapril .
D12.644.456.345.360.300 Enalaprilat .
D12.776 Proteins .
D12.776.157 Carrier Proteins .
D12.776.157.530 Membrane Transport Proteins .
D12.776.157.530.450 Ion Pumps .
D12.776.157.530.450.625 Symporters .
D12.776.157.530.450.625.374 Sodium Chloride Symporters .
D12.776.157.530.450.625.374.500 Solute Carrier Family 12, Member 3 .
D12.776.157.530.937 Solute Carrier Proteins .
D12.776.157.530.937.750 Sodium-Potassium-Chloride Symporters .
D12.776.157.530.937.750.750 Solute Carrier Family 12, Member 3 .
D12.776.543 Membrane Proteins .
D12.776.543.585 Membrane Transport Proteins .
D12.776.543.585.937 Solute Carrier Proteins .
D12.776.543.585.937.875 Sodium-Potassium-Chloride Symporters .
D12.776.543.585.937.875.750 Solute Carrier Family 12, Member 3 .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.562 Membrane Transport Modulators .
D27.505.519.562.906 Sodium Potassium Chloride Symporter Inhibitors .
D27.505.696 Physiological Effects of Drugs .
D27.505.696.399 Hormones, Hormone Substitutes, and Hormone Antagonists .
D27.505.696.399.472 Hormones .
D27.505.696.399.472.673 Mineralocorticoids .
D27.505.696.560 Natriuretic Agents .
D27.505.696.560.500 Diuretics .
D27.505.696.560.500.931 Sodium Potassium Chloride Symporter Inhibitors .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Hydrochlorothiazide .
Dichlothiazide .
Dihydrochlorothiazide .
Esidrex .
Esidrix .
HCTZ 5279 .
HydroDIURIL .
Hypothiazide .
Oretic .
Sectrazide .
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism. .
1.00
1375641
 
Ethacrynic Acid .
Edecrin .
Etacrynic Acid .
Ethacrinic Acid .
Ethacrynate Sodium .
Ethacrynic Acid, Sodium Salt .
Hydromedin .
Acid, Etacrynic .
Acid, Ethacrinic .
Acid, Ethacrynic .
Sodium, Ethacrynate .
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. .
0.40
22138
 
Aldosterone .
Aldosterone, (+-)-Isomer .
Aldosterone, (11 beta,17 alpha)-Isomer .
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. .
0.40
14021294
 
Solute Carrier Family 12, Member 3 .
NCCT Protein .
Na-Cl Cotransporter .
Na-Cl Symporter .
Na-Cl Thiazide-Sensitive Cotransporter .
SLC12A3 Cotransporter .
SLC12A3 Protein .
Thiazide-Sensitive Sodium-Chloride Cotransporter .
Cotransporter, Na-Cl .
Cotransporter, Na-Cl Thiazide-Sensitive .
Cotransporter, SLC12A3 .
Cotransporter, Thiazide-Sensitive Sodium-Chloride .
Na Cl Cotransporter .
Na Cl Symporter .
Na Cl Thiazide Sensitive Cotransporter .
Protein, NCCT .
Protein, SLC12A3 .
Sodium-Chloride Cotransporter, Thiazide-Sensitive .
Symporter, Na-Cl .
Thiazide Sensitive Sodium Chloride Cotransporter .
Thiazide-Sensitive Cotransporter, Na-Cl .
Na-Cl cotransporter in the convoluted segments of the DISTAL KIDNEY TUBULE. It mediates active reabsorption of sodium and chloride and is inhibited by THIAZIDE DIURETICS. .
0.36
1345
 
Amiloride .
Amidal .
Amiduret Trom .
Amiloberag .
Amiloride Hydrochloride .
Amiloride Hydrochloride, Anhydrous .
Kaluril .
Midamor .
Midoride .
Modamide .
Anhydrous Amiloride Hydrochloride .
Hydrochloride, Amiloride .
Hydrochloride, Anhydrous Amiloride .
Trom, Amiduret .
A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) .
0.35
297289
 
Sodium Potassium Chloride Symporter Inhibitors .
Bumetanide Sensitive Na-K-Cl-Transporter Inhibitors .
High Ceiling Diuretics .
Loop Diuretics .
Na-K-CL Symporter Inhibitors .
Sodium Potassium Chloride Cotransporter Inhibitors .
Bumetanide Sensitive Na K Cl Transporter Inhibitors .
Ceiling Diuretics, High .
Diuretics, High Ceiling .
Diuretics, Loop .
Inhibitors, Na-K-CL Symporter .
Na K CL Symporter Inhibitors .
Symporter Inhibitors, Na-K-CL .
Agents that inhibit SODIUM-POTASSIUM-CHLORIDE SYMPORTERS which are concentrated in the thick ascending limb at the junction of the LOOP OF HENLE and KIDNEY TUBULES, DISTAL. They act as DIURETICS. Excess use is associated with HYPOKALEMIA and HYPERGLYCEMIA. .
0.35
2805
 
Mefruside .
A benzene-sulfonamide-furan. It is used as a diuretic that affects the concentrating ability of the KIDNEY, increases SODIUM CHLORIDE excretion, but may not spare POTASSIUM. It inhibits CARBONIC ANHYDRASES and may increase the blood URIC ACID level. .
0.34
057
 
Enalaprilat .
1-(N-((S)-1-Carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate .
Enalaprilat Anhydrous .
Enalaprilat Citrate, Anhydrous .
Enalaprilat Dihydrate .
Enalaprilat, (R)-Isomer, Anhydrous .
MK-422 .
Pres iv .
Vasotec .
Xanef .
Anhydrous Enalaprilat Citrate .
Anhydrous, Enalaprilat .
Dihydrate, Enalaprilat .
MK 422 .
MK422 .
Enalaprilic Acid .
MK-422 .
The active metabolite of ENALAPRIL and one of the potent, intravenously administered, ANGIOTENSIN-CONVERTING ENZYME INHIBITORS. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion. .
0.33
9784
 
Mineralocorticoids .
Mineralocorticoid Effect .
Mineralocorticoid Effects .
Effect, Mineralocorticoid .
Effects, Mineralocorticoid .
Mineralocorticoid Analogs .
Mineralocorticoids, Synthetic .
A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II. .
0.33
261931
 
Gitelman Syndrome .
Familial Hypokalemia-Hypomagnesemia .
Gitelman's Syndrome .
Hypokalemia-Hypomagnesemia, Primary Renotubular, with Hypocalciuria .
Hypomagnesemia-Hypokalemia, Primary Renotubular, with Hypocalciuria .
Potassium and Magnesium Depletion .
Primary Renotubular, Hypokalemia-Hypomagnesemia with Hypocalciuria .
Primary Renotubular, Hypomagnesemia-Hypokalemia with Hypocalciuria .
Tubular Hypomagnesemia-Hypokalemia with Hypocalcuria .
Familial Hypokalemia Hypomagnesemia .
Hypokalemia-Hypomagnesemia, Familial .
Syndrome, Gitelman .
Syndrome, Gitelman's .
Tubular Hypomagnesemia Hypokalemia with Hypocalcuria .
An inherited renal disorder characterized by defective NaCl reabsorption in the convoluted DISTAL KIDNEY TUBULE leading to HYPOKALEMIA. In contrast with BARTTER SYNDROME, Gitelman syndrome includes hypomagnesemia and normocalcemic hypocalciuria, and is caused by mutations in the thiazide-sensitive SODIUM-POTASSIUM-CHLORIDE SYMPORTERS. .
0.33
7262