serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.065 Amides .
D02.065.277 Benzamides .
D02.065.277.456 Imatinib Mesylate .
D02.241 Carboxylic Acids .
D02.241.223 Acids, Carbocyclic .
D02.241.223.100 Benzoates .
D02.241.223.100.100 Benzamides .
D02.241.223.100.100.435 Imatinib Mesylate .
D02.455 Hydrocarbons .
D02.455.426 Hydrocarbons, Cyclic .
D02.455.426.559 Hydrocarbons, Aromatic .
D02.455.426.559.389 Benzene Derivatives .
D02.455.426.559.389.127 Benzoates .
D02.455.426.559.389.127.085 Benzamides .
D02.455.426.559.389.127.085.465 Imatinib Mesylate .
D02.886 Sulfur Compounds .
D02.886.675 Thiazoles .
D02.886.675.184 Dasatinib .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.129 Azoles .
D03.383.129.708 Thiazoles .
D03.383.129.708.198 Dasatinib .
D03.383.606 Piperazines .
D03.383.606.405 Imatinib Mesylate .
D03.383.742 Pyrimidines .
D03.383.742.148 Dasatinib .
D03.383.742.349 Imatinib Mesylate .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.913 Transferases .
D08.811.913.696 Phosphotransferases .
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) .
D08.811.913.696.620.682 Protein Kinases .
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.500 Proto-Oncogene Proteins c-abl .
D08.811.913.696.620.682.725.500.500 Fusion Proteins, bcr-abl .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.602 Mutant Proteins .
D12.776.602.500 Mutant Chimeric Proteins .
D12.776.602.500.500 Oncogene Proteins, Fusion .
D12.776.602.500.500.100 Fusion Proteins, bcr-abl .
D12.776.624 Neoplasm Proteins .
D12.776.624.664 Oncogene Proteins .
D12.776.624.664.500 Oncogene Proteins, Fusion .
D12.776.624.664.500.100 Fusion Proteins, bcr-abl .
D12.776.624.664.700 Proto-Oncogene Proteins .
D12.776.624.664.700.171 Proto-Oncogene Proteins c-bcr .
D12.776.624.664.700.171.500 Fusion Proteins, bcr-abl .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.389 Enzyme Inhibitors .
D27.505.519.389.755 Protein Kinase Inhibitors .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Imatinib Mesylate .
Alpha-(4-methyl-1-piperazinyl)-3'-((4-(3-pyridyl)-2-pyrimidinyl)amino)-p-tolu-p-toluidide .
CGP 57148 .
CGP-57148 .
CGP57148B .
Gleevec .
Glivec .
Imatinib .
Imatinib Methanesulfonate .
ST 1571 .
ST1571 .
STI 571 .
STI-571 .
STI571 .
CGP57148 .
Mesylate, Imatinib .
Methanesulfonate, Imatinib .
A tyrosine kinase inhibitor and ANTINEOPLASTIC AGENT that inhibits the BCR-ABL kinase created by chromosome rearrangements in CHRONIC MYELOID LEUKEMIA and ACUTE LYMPHOBLASTIC LEUKEMIA, as well as PDG-derived tyrosine kinases that are overexpressed in gastrointestinal stromal tumors. .
1.00
209063
 
Fusion Proteins, bcr-abl .
Bcr-Abl Tyrosine Kinase .
Oncogene Protein p185(bcr-abl) .
Oncogene Protein p230(bcr-abl) .
p185(bcr-abl) Fusion Proteins .
p190(bcr-abl) Fusion Proteins .
p210(bcr-abl) Fusion Proteins .
p230(bcr-abl) Fusion Proteins .
Bcr Abl Tyrosine Kinase .
Fusion Proteins, bcr abl .
Kinase, Bcr-Abl Tyrosine .
Tyrosine Kinase, Bcr-Abl .
bcr abl Fusion Proteins .
Oncogene Protein p190(bcr-abl) .
Oncogene Protein p210(bcr-abl) .
bcr-abl Fusion Proteins .
Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC. .
0.47
345799
 
Protein-Tyrosine Kinases .
Protein-Tyrosine Kinase .
Tyrosine Kinase .
Tyrosine Protein Kinases .
Tyrosine-Specific Protein Kinases .
Tyrosylprotein Kinase .
Kinase, Protein-Tyrosine .
Kinase, Tyrosine .
Kinase, Tyrosine Protein .
Kinase, Tyrosine-Specific Protein .
Kinase, Tyrosylprotein .
Kinases, Protein-Tyrosine .
Kinases, Tyrosine Protein .
Kinases, Tyrosine-Specific Protein .
Protein Kinase, Tyrosine-Specific .
Protein Kinases, Tyrosine .
Protein Kinases, Tyrosine-Specific .
Protein Tyrosine Kinase .
Protein Tyrosine Kinases .
Tyrosine Specific Protein Kinase .
Tyrosine Specific Protein Kinases .
Tyrosine Protein Kinase .
Tyrosine-Specific Protein Kinase .
Protein-Tyrosine Kinase .
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors. .
0.45
11533326
 
Dasatinib .
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide .
BMS 354825 .
BMS-354825 .
BMS354825 .
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide .
Sprycel .
354825, BMS .
A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB. .
0.42
21562
 
Protein Kinase Inhibitors .
Inhibitors, Protein Kinase .
Kinase Inhibitors, Protein .
Agents that inhibit PROTEIN KINASES. .
0.41
6935524