serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.074 DNA Repair Enzymes .
D08.811.074.062 AlkB Enzymes .
D08.811.074.062.500 AlkB Homolog 1, Histone H2a Dioxygenase .
D08.811.074.062.750 AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase .
D08.811.074.062.875 AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase .
D08.811.074.062.937 AlkB Homolog 5, RNA Demethylase .
D08.811.074.062.968 Alpha-Ketoglutarate-Dependent Dioxygenase FTO .
D08.811.682 Oxidoreductases .
D08.811.682.662 Oxidoreductases Acting on CH-NH Group Donors .
D08.811.682.662.582 Oxidoreductases, N-Demethylating .
D08.811.682.662.582.138 AlkB Homolog 4, Lysine Demethylase .
D08.811.682.662.582.207 AlkB Homolog 5, RNA Demethylase .
D08.811.682.662.582.242 Alpha-Ketoglutarate-Dependent Dioxygenase FTO .
D08.811.682.690 Oxygenases .
D08.811.682.690.416 Dioxygenases .
D08.811.682.690.416.139 AlkB Enzymes .
D08.811.682.690.416.139.500 AlkB Homolog 1, Histone H2a Dioxygenase .
D08.811.682.690.416.139.750 AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase .
D08.811.682.690.416.139.875 AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase .
D08.811.682.690.416.139.937 AlkB Homolog 4, Lysine Demethylase .
D08.811.682.690.416.139.968 AlkB Homolog 5, RNA Demethylase .
D08.811.682.690.416.139.992 Alpha-Ketoglutarate-Dependent Dioxygenase FTO .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
AlkB Enzymes .
AlkB Homologs .
Alkylated DNA Repair Protein AlkB Homologs .
Alkylation Repair Homolog Proteins .
Alkylation Repair Homologs .
Enzymes, AlkB .
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE). .
1.00
010
 
Alpha-Ketoglutarate-Dependent Dioxygenase FTO .
AlkB Homolog 9 Protein .
Alpha-Ketoglutarate-Dependent Dioxygenase .
Fat Mass and Obesity Associated (FTO) Protein .
Fat Mass and Obesity Associated Protein .
Alpha Ketoglutarate Dependent Dioxygenase .
Alpha Ketoglutarate Dependent Dioxygenase FTO .
Dioxygenase, Alpha-Ketoglutarate-Dependent .
FTO, Alpha-Ketoglutarate-Dependent Dioxygenase .
A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS. .
0.68
1764
 
AlkB Homolog 1, Histone H2a Dioxygenase .
ALKBH Protein .
Alkylated DNA Repair Protein AlkB Homolog 1 .
Alpha-Ketoglutarate-Dependent Dioxygenase ABH1 .
DNA Lyase ABH1 .
DNA Oxidative Demethylase ALKBH1 .
ABH1, Alpha-Ketoglutarate-Dependent Dioxygenase .
ABH1, DNA Lyase .
Alpha Ketoglutarate Dependent Dioxygenase ABH1 .
A dioxygenase and alkylation repair homolog that functions by oxidative demethylation in RNA and DNA REPAIR of substrates which contain 3-methylcytosine. It also functions as one of the HISTONE DEMETHYLASES involved in embryonic development and maintaining the pluripotency of EMBRYONIC STEM CELLS. .
0.60
034
 
AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase .
Alkylated DNA Repair Protein AlkB Homolog 2 .
Alpha-ketoglutarate-Dependent Dioxygenase AlkB Homolog 2 .
DNA Oxidative Demethylase ALKBH2 .
Oxy DC1 Protein .
AlkB Homolog 2, Alpha Ketoglutarate Dependent Dioxygenase .
Alpha ketoglutarate Dependent Dioxygenase AlkB Homolog 2 .
A dioxygenase and alkylation repair homolog that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. It can also repair alkylated DNA containing 1-ethenoadenine in vitro. It has highest affinity for double-stranded DNA. .
0.60
039
 
AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase .
Alkylated DNA Repair Protein AlkB Homolog 3 .
Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 .
Prostate Cancer Antigen 1 .
AlkB Homolog 3, Alpha Ketoglutarate Dependent Dioxygenase .
Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 3 .
A dioxygenase and alkylation repair homolog that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. It has a strong preference for SINGLE-STRANDED DNA and may also act on RNA. .
0.59
134
 
AlkB Homolog 4, Lysine Demethylase .
Alkylated DNA Repair Protein AlkB Homolog 4 .
Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 .
Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4 .
A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation. .
0.59
010
 
AlkB Homolog 5, RNA Demethylase .
Alkylated DNA Repair Protein AlkB Homolog 5 .
Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5 .
RNA Demethylase ALKBH5 .
ALKBH5, RNA Demethylase .
Alpha Ketoglutarate Dependent Dioxygenase AlkB Homolog 5 .
Demethylase ALKBH5, RNA .
A dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA. .
0.59
021