serw-MX  [xml]  

 DeCS Categories

D02 Organic Chemicals .
D02.455 Hydrocarbons .
D02.455.526 Hydrocarbons, Halogenated .
D02.455.526.728 Mustard Compounds .
D02.455.526.728.650 Nitrogen Mustard Compounds .
D02.455.526.728.650.050 Aniline Mustard .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
 Synonyms & Historicals
Aniline Mustard .
Lymphochin .
Lymphocin .
Lymphoquin .
N,N-Di(2-Chloroethyl)aniline .
N,N-bis(2-chloroethyl)aniline .
N,N-bis-(2-chloroethyl)aniline .
Mustard, Aniline .
Alkylating anti-neoplastic agent. .
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .