Mitolactol. NSC-104800 . NSC 104800 . NSC104800 . Dibromodulcitol . Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs. . 1.00
Antineoplastic Agents, Alkylating. Alkylating Antineoplastic Agents . Alkylating Antineoplastic Drugs . Alkylating Antineoplastics . Alkylating Drugs, Antineoplastic . Antineoplastic Alkylating Agents . Antineoplastic Drugs, Alkylating . Antineoplastics, Alkylating . Antineoplastic Alkylating Drugs . Drugs, Antineoplastic Alkylating . Alkylating Agents, Antineoplastic . A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) . 0.47
Triethylenemelamine. 2,4,6-Triethylimino-1,3,5-Triazine . Triethylene Melamine . Melamine, Triethylene . Tretamine . Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. . 0.43
Bone Marrow. Marrow, Bone . Marrow, Red . Marrow, Yellow . Marrow . Red Marrow . Yellow Marrow . The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. . 0.38
