serw-MX  [xml]  

 DeCS Categories

A15 Hemic and Immune Systems .
A15.382 Immune System .
A15.382.216 Bone Marrow .
D02 Organic Chemicals .
D02.033 Alcohols .
D02.033.800 Sugar Alcohols .
D02.033.800.400 Galactitol .
D02.033.800.400.500 Mitolactol .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.097 Azirines .
D03.383.097.217 Aziridines .
D03.383.097.217.924 Triethylenemelamine .
D03.383.931 Triazines .
D03.383.931.915 Triethylenemelamine .
D09 Carbohydrates .
D09.853 Sugar Alcohols .
D09.853.400 Galactitol .
D09.853.400.500 Mitolactol .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
 Synonyms & Historicals
Mitolactol .
NSC-104800 .
NSC 104800 .
NSC104800 .
Dibromodulcitol .
Alkylating antineoplastic toxic to bone marrow; used in breast cancer, also in combination with other drugs. .
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .
Triethylenemelamine .
2,4,6-Triethylimino-1,3,5-Triazine .
Triethylene Melamine .
Melamine, Triethylene .
Tretamine .
Toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers. .
Bone Marrow .
Marrow, Bone .
Marrow, Red .
Marrow, Yellow .
Marrow .
Red Marrow .
Yellow Marrow .
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells. .