Azirines. Azacyclopropanes, Unsaturated . Unsaturated Azacyclopropanes . Unsaturated azacyclopropane compounds that are three-membered heterocycles of a nitrogen and two carbon atoms. . 1.00
Zidovudine. 3'-Azido-2',3'-Dideoxythymidine . 3'-Azido-3'-deoxythymidine . AZT Antiviral . AZT, Antiviral . BW A509U . BWA-509U . Retrovir . 3' Azido 2',3' Dideoxythymidine . 3' Azido 3' deoxythymidine . Antiviral AZT . BWA 509U . BWA509U . Azidothymidine . AZT (Antiviral) . A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. . 0.49
Sodium Azide. Azide, Sodium . NaN3 21302 . A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed) . 0.47
Thiotepa. AI3-24916 . Girostan . NSC-6396 . Tespa . Tespamin . Tris(1-aziridinyl)phosphine Sulfide . AI3 24916 . AI324916 . NSC 6396 . NSC6396 . Thio Tepa . Thiophosphamide . Thio-Tepa . Triethylenethiophosphoramide . A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed). . 0.46