serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.033 Alcohols .
D02.033.800 Sugar Alcohols .
D02.033.800.609 Mannitol .
D02.033.800.609.500 Mitobronitol .
D02.455 Hydrocarbons .
D02.455.526 Hydrocarbons, Halogenated .
D02.455.526.728 Mustard Compounds .
D02.455.526.728.650 Nitrogen Mustard Compounds .
D02.455.526.728.650.730 Phosphoramide Mustards .
D02.455.526.728.650.730.243 Cyclophosphamide .
D02.455.526.728.650.730.243.250 Ifosfamide .
D02.654 Nitroso Compounds .
D02.654.692 Nitrosourea Compounds .
D02.654.692.440 Lomustine .
D02.654.692.440.700 Semustine .
D02.705 Organophosphorus Compounds .
D02.705.672 Phosphoramides .
D02.705.672.500 Phosphoramide Mustards .
D02.705.672.500.243 Cyclophosphamide .
D02.705.672.500.243.250 Ifosfamide .
D02.948 Urea 11093 .
D02.948.594 Nitrosourea Compounds .
D02.948.594.440 Lomustine .
D02.948.594.440.700 Semustine .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.533 Oxazines .
D03.383.533.500 Ifosfamide .
D03.383.606 Piperazines .
D03.383.606.773 Pipobroman .
D09 Carbohydrates .
D09.853 Sugar Alcohols .
D09.853.609 Mannitol .
D09.853.609.500 Mitobronitol .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Mitobronitol .
Myelobromol .
NSC-94,100 .
NSC-94100 .
NSC 94,100 .
NSC 94100 .
NSC94,100 .
NSC94100 .
Dibromomannitol .
Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent. .
1.00
050
 
Pipobroman .
Vercyte .
An antineoplastic agent that acts by alkylation. .
0.55
080
 
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .
0.54
399137
 
Ifosfamide .
Asta Z 4942 .
Holoxan .
Iphosphamide .
Iso-Endoxan .
NSC-109,724 .
NSC-109724 .
Iso Endoxan .
NSC 109,724 .
NSC 109724 .
NSC109,724 .
NSC109724 .
Isofosfamide .
Isophosphamide .
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent. .
0.54
264574
 
Alkylating Agents .
Alkylators .
Agents, Alkylating .
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. .
0.53
406645
 
Semustine .
Me-CCNU .
MeCCNU .
NSC-95441 .
Me CCNU .
Methyl CCNU .
NSC 95441 .
NSC95441 .
Methyl-CCNU .
4-Methyl derivative of LOMUSTINE; (CCNU). An antineoplastic agent which functions as an alkylating agent. .
0.50
1469