Amyotrophic Lateral Sclerosis. ALS (Amyotrophic Lateral Sclerosis) . Amyotrophic Lateral Sclerosis With Dementia . Amyotrophic Lateral Sclerosis, Guam Form . Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam . Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 . Charcot Disease . Dementia With Amyotrophic Lateral Sclerosis . Gehrig's Disease . Guam Disease . Guam Form of Amyotrophic Lateral Sclerosis . Lou Gehrig's Disease . Lou-Gehrigs Disease . Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 . Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam . Disease, Guam . Disease, Lou-Gehrigs . Gehrig Disease . Gehrigs Disease . Sclerosis, Amyotrophic Lateral . Lou Gehrig Disease . Motor Neuron Disease, Amyotrophic Lateral Sclerosis . GEHRIG'S DISEASE . LOU GEHRIG'S DISEASE . A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) . 1.00
Charcot-Marie-Tooth Disease. Charcot-Marie Disease . Charcot-Marie-Tooth Disease, Autosomal Dominant, With Focally Folded Myelin Sheaths, Type 1A . Charcot-Marie-Tooth Disease, Autosomal Dominant, with Focally Folded Myelin Sheaths, Type 1B . Charcot-Marie-Tooth Disease, Demyelinating, Type 1A . Charcot-Marie-Tooth Disease, Demyelinating, Type 1B . Charcot-Marie-Tooth Disease, Slow Nerve Conduction Type, Linked To Duffy . Charcot-Marie-Tooth Disease, Type 1A . Charcot-Marie-Tooth Disease, Type 1B . Charcot-Marie-Tooth Disease, Type I . Charcot-Marie-Tooth Disease, Type IA . Charcot-Marie-Tooth Disease, Type IB . Charcot-Marie-Tooth Disease, Type II . Charcot-Marie-Tooth Hereditary Neuropathy . Charcot-Marie-Tooth Neuropathy, Type 1A . Charcot-Marie-Tooth Neuropathy, Type 1B . Charcot-Marie-Tooth Syndrome . HMN Distal Type I . HMSN 1A . HMSN 1B . HMSN I . HMSN IA . HMSN IB . HMSN II . HMSN1A . HMSN1B . Hereditary Areflexic Dystasia . Hereditary Motor And Sensory Neuropathy IB . Hereditary Motor and Sensory Neuropathy 1A . Hereditary Motor and Sensory Neuropathy 1B . Hereditary Motor and Sensory Neuropathy IA . Hereditary Type I Motor and Sensory Neuropathy . Neuropathy, Type I Hereditary Motor and Sensory . Neuropathy, Type II Hereditary Motor and Sensory . Roussy Levy Hereditary Areflexic Dystasia . Roussy-Levy Disease . Roussy-Levy Hereditary Areflexic Dystasia . Areflexic Dystasia, Hereditary . Areflexic Dystasias, Hereditary . Atrophies, Peroneal Muscular . Atrophy, Peroneal Muscular . Charcot Marie Disease . Charcot Marie Tooth Disease . Charcot Marie Tooth Disease, Type 1A . Charcot Marie Tooth Disease, Type 1B . Charcot Marie Tooth Disease, Type I . Charcot Marie Tooth Disease, Type IA . Charcot Marie Tooth Disease, Type IB . Charcot Marie Tooth Disease, Type II . Charcot Marie Tooth Hereditary Neuropathy . Charcot Marie Tooth Neuropathy, Type 1A . Charcot Marie Tooth Neuropathy, Type 1B . Charcot Marie Tooth Syndrome . Dystasia, Hereditary Areflexic . Dystasias, Hereditary Areflexic . Hereditary Areflexic Dystasias . Hereditary Motor and Sensory Neuropathy Type II . Hereditary Neuropathy, Charcot-Marie-Tooth . Muscular Atrophies, Peroneal . Peroneal Muscular Atrophies . Roussy Levy Disease . Roussy Levy Syndrome . Syndrome, Charcot-Marie-Tooth . Syndrome, Roussy-Levy . Atrophy, Muscular, Peroneal . Muscular Atrophy, Peroneal . Peroneal Muscular Atrophy . Hereditary Motor, and Sensory Neuropathy Type I . Hereditary Motor and Sensory-Neuropathy Type II . HMSN Type I . HMSN Type II . Roussy-Levy Syndrome . HERDITARY MOTOR, AND SENSORY NEUROPATHY TYPE I . HMN DISTAL TYPE I . HEREDITARY TYPE I MOTOR AND SENSORY NEUROPATHY . NEUROPATHY, TYPE I HEREDITARY MOTOR AND SENSORY . CHARCOT-MARIE DISEASE . A hereditary motor and sensory neuropathy transmitted most often as an autosomal dominant trait and characterized by progressive distal wasting and loss of reflexes in the muscles of the legs (and occasionally involving the arms). Onset is usually in the second to fourth decade of life. This condition has been divided into two subtypes, hereditary motor and sensory neuropathy (HMSN) types I and II. HMSN I is associated with abnormal nerve conduction velocities and nerve hypertrophy, features not seen in HMSN II. (Adams et al., Principles of Neurology, 6th ed, p1343) . 0.76
Chagas Disease. American Trypanosomiasis . Chagas' Disease . Trypanosoma cruzi Infection . Infection, Trypanosoma cruzi . Infections, Trypanosoma cruzi . South American Trypanosomiasis . Trypanosoma cruzi Infections . Trypanosomiasis, American . Trypanosomiasis, South American . Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. . 0.71
Disease. Diseases . Illness . Disease Concept Evolution . A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. . 0.63
Immunoproliferative Small Intestinal Disease. Disease, alpha-Chain . Diseases, alpha-Chain . Mediterranean Lymphoma . alpha Chain Disease . alpha-Chain Diseases . alpha-Chain Disease . Heavy Chain Disease, IgA Type . IPSID . Lymphoma, Mediterranean . A condition that is caused by HYPERPLASIA of LYMPHOCYTES in the small intestine (INTESTINE, SMALL) and the mesenteric LYMPH NODES. These lymphocytes produce an anomalous alpha heavy chain protein. Generally, these IPSID patients have either concurrent LYMPHOMA or develop lymphoma within a few years. The disease was first described in the Mediterranean region and is characterized by malabsorption; WEIGHT LOSS; DIARRHEA; and STEATORRHEA. . 0.62
