Tetanus. Clostridium tetani Infection . Clostridium tetani Infections . Infection, Clostridium tetani . Infections, Clostridium tetani . A disease caused by tetanospasmin, a powerful protein toxin produced by CLOSTRIDIUM TETANI. Tetanus usually occurs after an acute injury, such as a puncture wound or laceration. Generalized tetanus, the most common form, is characterized by tetanic muscular contractions and hyperreflexia. Localized tetanus presents itself as a mild condition with manifestations restricted to muscles near the wound. It may progress to the generalized form. . 1.00
Clostridium tetani. The cause of TETANUS in humans and domestic animals. It is a common inhabitant of human and horse intestines as well as soil. Two components make up its potent exotoxin activity, a neurotoxin and a hemolytic toxin. . 0.84
Tetanus Toxin. Tetanus Toxins . Neurotoxin, Clostridial . Toxin, Clostridium tetani . Toxin, Tetanus . Toxins, Tetanus . Clostridial Neurotoxin . Clostridium tetani Toxin . Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS. . 0.72
