Meningomyelocele. Acquired Meningomyelocele . Myelomeningocele, Acquired . Acquired Meningomyeloceles . Acquired Myelomeningocele . Acquired Myelomeningoceles . Meningomyelocele, Acquired . Meningomyeloceles . Meningomyeloceles, Acquired . Myeloceles . Myelomeningoceles . Myelomeningoceles, Acquired . Myelocele . Myelomeningocele . Congenital, or rarely acquired, herniation of meningeal and spinal cord tissue through a bony defect in the vertebral column. The majority of these defects occur in the lumbosacral region. Clinical features include PARAPLEGIA, loss of sensation in the lower body, and incontinence. This condition may be associated with the ARNOLD-CHIARI MALFORMATION and HYDROCEPHALUS. (From Joynt, Clinical Neurology, 1992, Ch55, pp35-6) . 1.00
Lithiasis. Calculoses . Lithiases . Calculosis . A condition characterized by the formation of CALCULI and concretions in the hollow organs or ducts of the body. They occur most often in the gallbladder, kidney, and lower urinary tract. . 0.36
Spina Bifida Occulta. Occult Spina Bifida . Closed Spinal Bifida . Sinus, Dermal . Spina Bifida, Occult . Dermal Sinus . Spinal Bifida, Closed . OCCULT SPINA BIFIDA . OCCULT SPINAL DYSRAPHISM . A common congenital midline defect of fusion of the vertebral arch without protrusion of the spinal cord or meninges. The lesion is also covered by skin. L5 and S1 are the most common vertebrae involved. The condition may be associated with an overlying area of hyperpigmented skin, a dermal sinus, or an abnormal patch of hair. The majority of individuals with this malformation are asymptomatic although there is an increased incidence of tethered cord syndrome and lumbar SPONDYLOSIS. (From Joynt, Clinical Neurology, 1992, Ch55, p34) . 0.35
Dry Eye Syndromes. Dry Eye Syndrome . Syndrome, Dry Eye . Syndromes, Dry Eye . Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur. . 0.35
Retinoblastoma. Eye Cancer, Retinoblastoma . Familial Retinoblastoma . Hereditary Retinoblastoma . Sporadic Retinoblastoma . Familial Retinoblastomas . Glioblastomas, Retinal . Gliomas, Retinal . Hereditary Retinoblastomas . Neuroblastomas, Retinal . Retinal Glioblastoma . Retinal Glioblastomas . Retinal Glioma . Retinal Gliomas . Retinal Neuroblastoma . Retinal Neuroblastomas . Retinoblastoma, Familial . Retinoblastoma, Hereditary . Retinoblastoma, Sporadic . Retinoblastomas . Retinoblastomas, Familial . Retinoblastomas, Hereditary . Retinoblastomas, Sporadic . Sporadic Retinoblastomas . Glioblastoma, Retinal . Glioma, Retinal . Neuroblastoma, Retinal . A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104) . 0.33
Porphyrias. Porphyria . Porphyrin Disorder . Disorder, Porphyrin . Disorders, Porphyrin . Porphyrin Disorders . A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues. . 0.32
