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 DeCS Categories

D08 Enzymes and Coenzymes .
D08.244 Cytochromes .
D08.244.453 Cytochrome P-450 Enzyme System .
D08.244.453.005 Aryl Hydrocarbon Hydroxylases .
D08.244.453.005.443 Cytochrome P-450 CYP1A2 .
D08.244.453.012 Camphor 5-Monooxygenase .
D08.244.453.100 Cytochrome P450 Family 1 .
D08.244.453.100.750 Cytochrome P-450 CYP1A2 .
D08.244.453.489 Cytochrome P450 Family 19 .
D08.244.453.489.500 Aromatase .
D08.244.453.491 Cytochrome P450 Family 2 .
D08.244.453.491.375 Cytochrome P-450 CYP2E1 .
D08.244.453.860 Cytochrome P450 Family 3 .
D08.244.453.860.500 Cytochrome P-450 CYP3A .
D08.244.453.915 Steroid Hydroxylases .
D08.244.453.915.099 Aromatase .
D08.811 Enzymes .
D08.811.682 Oxidoreductases .
D08.811.682.662 Oxidoreductases Acting on CH-NH Group Donors .
D08.811.682.662.582 Oxidoreductases, N-Demethylating .
D08.811.682.662.582.338 Cytochrome P-450 CYP2E1 .
D08.811.682.662.582.353 Cytochrome P-450 CYP3A .
D08.811.682.690 Oxygenases .
D08.811.682.690.708 Mixed Function Oxygenases .
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System .
D08.811.682.690.708.170.010 Aryl Hydrocarbon Hydroxylases .
D08.811.682.690.708.170.010.443 Cytochrome P-450 CYP1A2 .
D08.811.682.690.708.170.012 Camphor 5-Monooxygenase .
D08.811.682.690.708.170.020 Cytochrome P450 Family 1 .
D08.811.682.690.708.170.020.750 Cytochrome P-450 CYP1A2 .
D08.811.682.690.708.170.447 Cytochrome P450 Family 19 .
D08.811.682.690.708.170.447.500 Aromatase .
D08.811.682.690.708.170.450 Cytochrome P450 Family 2 .
D08.811.682.690.708.170.450.375 Cytochrome P-450 CYP2E1 .
D08.811.682.690.708.170.495 Cytochrome P450 Family 3 .
D08.811.682.690.708.170.495.500 Cytochrome P-450 CYP3A .
D08.811.682.690.708.170.915 Steroid Hydroxylases .
D08.811.682.690.708.170.915.099 Aromatase .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.422 Hemeproteins .
D12.776.422.220 Cytochromes .
D12.776.422.220.453 Cytochrome P-450 Enzyme System .
D12.776.422.220.453.010 Aryl Hydrocarbon Hydroxylases .
D12.776.422.220.453.010.443 Cytochrome P-450 CYP1A2 .
D12.776.422.220.453.012 Camphor 5-Monooxygenase .
D12.776.422.220.453.100 Cytochrome P450 Family 1 .
D12.776.422.220.453.100.750 Cytochrome P-450 CYP1A2 .
D12.776.422.220.453.489 Cytochrome P450 Family 19 .
D12.776.422.220.453.489.500 Aromatase .
D12.776.422.220.453.491 Cytochrome P450 Family 2 .
D12.776.422.220.453.491.375 Cytochrome P-450 CYP2E1 .
D12.776.422.220.453.860 Cytochrome P450 Family 3 .
D12.776.422.220.453.860.500 Cytochrome P-450 CYP3A .
D12.776.422.220.453.915 Steroid Hydroxylases .
D12.776.422.220.453.915.099 Aromatase .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Cytochrome P-450 Enzyme System .
CYP450 Family .
CYP450 Superfamily .
Cytochrome P-450 Enzymes .
Cytochrome P-450 Families .
Cytochrome P-450 Monooxygenase .
Cytochrome P-450 Oxygenase .
Cytochrome P-450 Superfamily .
Cytochrome P450 .
Cytochrome P450 Superfamily .
Cytochrome p450 Families .
P-450 Enzymes .
P450 Enzymes .
Cytochrome P 450 .
Cytochrome P 450 Dependent Monooxygenase .
Cytochrome P 450 Enzyme System .
Cytochrome P 450 Enzymes .
Cytochrome P 450 Families .
Cytochrome P 450 Monooxygenase .
Cytochrome P 450 Oxygenase .
Cytochrome P 450 Superfamily .
Enzymes, Cytochrome P-450 .
Enzymes, P-450 .
Enzymes, P450 .
Monooxygenase, Cytochrome P-450 .
Monooxygenase, Cytochrome P-450-Dependent .
P 450 Enzymes .
P-450 Enzymes, Cytochrome .
Superfamily, CYP450 .
Superfamily, Cytochrome P-450 .
Superfamily, Cytochrome P450 .
Cytochrome P-450 .
Cytochrome P-450-Dependent Monooxygenase .
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. .
1.00
4439776
 
Cytochrome P-450 CYP1A2 .
CYP 1A2 .
Caffeine Demethylase .
Cytochrome P-450 LM(4) .
Cytochrome P-450 LM4 .
Cytochrome P-450d .
Cytochrome P450 1A2 .
CYP1A2, Cytochrome P-450 .
Cytochrome P 450 CYP1A2 .
Cytochrome P 450 LM4 .
Cytochrome P 450d .
Demethylase, Caffeine .
O-Dealkylase, Phenacetin .
P-450 LM4, Cytochrome .
Phenacetin O Dealkylase .
CYP1A2 .
Phenacetin O-Dealkylase .
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN. .
0.95
22801
 
Cytochrome P-450 CYP2E1 .
CYP 2E1 .
CYP IIE1 .
CYPIIE1 .
Cytochrome P-450 (ALC) .
Cytochrome P-450 IIE1 .
Cytochrome P-450-J .
Cytochrome P450 2E1 .
N-Nitrosodimethylamine Demethylase .
4 Nitrophenol 2 Hydroxylase .
Cytochrome P 450 CYP2E1 .
Cytochrome P 450 IIE1 .
Cytochrome P 450 J .
Dimethylnitrosamine N Demethylase .
N Nitrosodimethylamine Demethylase .
CYP2E1 .
Dimethylnitrosamine N-Demethylase .
4-Nitrophenol-2-Hydroxylase .
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse. .
0.89
93257
 
Camphor 5-Monooxygenase .
CYP101 .
Camphor-5-Monooxygenase .
Cytochrome P-450 101 .
Cytochrome P-450-cam .
Cytochrome P450(cam) .
P450cam .
Camphor 5 Monooxygenase .
Cytochrome P 450 101 .
Cytochrome P 450 cam .
Cytochrome P-450(cam) .
A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site. .
0.88
0429
 
Aromatase .
Androstenedione Aromatase .
CYP 19 .
CYP19 Protein .
Cytochrome P450 19 .
Estrogen Synthase .
Estrogen Synthetase .
P450AROM .
Aromatase, Androstenedione .
Cytochrome P 450 CYP19 .
Protein, CYP19 .
Cytochrome P-450(AROM) .
Cytochrome P-450 CYP19 .
CYP19 .
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system. .
0.88
455736
 
Cytochrome P-450 CYP3A .
CYP3A4 .
CYP3A5 .
Cytochrome P-450 CYP3A4 .
Cytochrome P-450 CYP3A5 .
Cytochrome P-450IIIA .
Cytochrome P450 3A .
Cytochrome P450 3A4 .
Cytochrome P450 3A5 .
Erythromycin N-Demethylase .
Taurochenodeoxycholate 6-alpha-Monooxygenase .
3A5, Cytochrome P450 .
6-alpha-Monooxygenase, Taurochenodeoxycholate .
Cytochrome P 450 CYP3A .
Cytochrome P 450 CYP3A4 .
Cytochrome P 450 CYP3A5 .
Cytochrome P 450IIIA .
Erythromycin N Demethylase .
N-Demethylase, Erythromycin .
P-450 CYP3A, Cytochrome .
P-450 CYP3A4, Cytochrome .
P-450 CYP3A5, Cytochrome .
P-450IIIA, Cytochrome .
P450 3A, Cytochrome .
P450 3A5, Cytochrome .
Taurochenodeoxycholate 6 alpha Monooxygenase .
CYP3A .
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN. .
0.86
57569