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 DeCS Categories

D08 Enzymes and Coenzymes .
D08.244 Cytochromes .
D08.244.453 Cytochrome P-450 Enzyme System .
D08.244.453.005 Aryl Hydrocarbon Hydroxylases .
D08.244.453.005.500 Cytochrome P-450 CYP1B1 .
D08.244.453.012 Camphor 5-Monooxygenase .
D08.244.453.100 Cytochrome P450 Family 1 .
D08.244.453.100.875 Cytochrome P-450 CYP1B1 .
D08.244.453.484 Cytochrome P450 Family 11 .
D08.244.453.484.250 Cholesterol Side-Chain Cleavage Enzyme .
D08.244.453.484.500 Cytochrome P-450 CYP11B2 .
D08.244.453.489 Cytochrome P450 Family 19 .
D08.244.453.489.500 Aromatase .
D08.244.453.493 Cytochrome P450 Family 21 .
D08.244.453.493.500 Steroid 21-Hydroxylase .
D08.244.453.860 Cytochrome P450 Family 3 .
D08.244.453.860.500 Cytochrome P-450 CYP3A .
D08.244.453.890 Cytochrome P450 Family 7 .
D08.244.453.890.500 Cholesterol 7-alpha-Hydroxylase .
D08.244.453.915 Steroid Hydroxylases .
D08.244.453.915.050 Cytochrome P-450 CYP11B2 .
D08.244.453.915.099 Aromatase .
D08.244.453.915.200 Cholesterol 7-alpha-Hydroxylase .
D08.244.453.915.212 Cholesterol Side-Chain Cleavage Enzyme .
D08.244.453.915.760 Steroid 21-Hydroxylase .
D08.811 Enzymes .
D08.811.682 Oxidoreductases .
D08.811.682.662 Oxidoreductases Acting on CH-NH Group Donors .
D08.811.682.662.582 Oxidoreductases, N-Demethylating .
D08.811.682.662.582.353 Cytochrome P-450 CYP3A .
D08.811.682.690 Oxygenases .
D08.811.682.690.708 Mixed Function Oxygenases .
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System .
D08.811.682.690.708.170.010 Aryl Hydrocarbon Hydroxylases .
D08.811.682.690.708.170.010.500 Cytochrome P-450 CYP1B1 .
D08.811.682.690.708.170.012 Camphor 5-Monooxygenase .
D08.811.682.690.708.170.020 Cytochrome P450 Family 1 .
D08.811.682.690.708.170.020.875 Cytochrome P-450 CYP1B1 .
D08.811.682.690.708.170.425 Cytochrome P450 Family 11 .
D08.811.682.690.708.170.425.250 Cholesterol Side-Chain Cleavage Enzyme .
D08.811.682.690.708.170.425.500 Cytochrome P-450 CYP11B2 .
D08.811.682.690.708.170.447 Cytochrome P450 Family 19 .
D08.811.682.690.708.170.447.500 Aromatase .
D08.811.682.690.708.170.463 Cytochrome P450 Family 21 .
D08.811.682.690.708.170.463.500 Steroid 21-Hydroxylase .
D08.811.682.690.708.170.495 Cytochrome P450 Family 3 .
D08.811.682.690.708.170.495.500 Cytochrome P-450 CYP3A .
D08.811.682.690.708.170.890 Cytochrome P450 Family 7 .
D08.811.682.690.708.170.890.500 Cholesterol 7-alpha-Hydroxylase .
D08.811.682.690.708.170.915 Steroid Hydroxylases .
D08.811.682.690.708.170.915.050 Cytochrome P-450 CYP11B2 .
D08.811.682.690.708.170.915.099 Aromatase .
D08.811.682.690.708.170.915.200 Cholesterol 7-alpha-Hydroxylase .
D08.811.682.690.708.170.915.212 Cholesterol Side-Chain Cleavage Enzyme .
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.422 Hemeproteins .
D12.776.422.220 Cytochromes .
D12.776.422.220.453 Cytochrome P-450 Enzyme System .
D12.776.422.220.453.010 Aryl Hydrocarbon Hydroxylases .
D12.776.422.220.453.010.500 Cytochrome P-450 CYP1B1 .
D12.776.422.220.453.012 Camphor 5-Monooxygenase .
D12.776.422.220.453.100 Cytochrome P450 Family 1 .
D12.776.422.220.453.100.875 Cytochrome P-450 CYP1B1 .
D12.776.422.220.453.484 Cytochrome P450 Family 11 .
D12.776.422.220.453.484.250 Cholesterol Side-Chain Cleavage Enzyme .
D12.776.422.220.453.484.500 Cytochrome P-450 CYP11B2 .
D12.776.422.220.453.489 Cytochrome P450 Family 19 .
D12.776.422.220.453.489.500 Aromatase .
D12.776.422.220.453.493 Cytochrome P450 Family 21 .
D12.776.422.220.453.493.500 Steroid 21-Hydroxylase .
D12.776.422.220.453.860 Cytochrome P450 Family 3 .
D12.776.422.220.453.860.500 Cytochrome P-450 CYP3A .
D12.776.422.220.453.890 Cytochrome P450 Family 7 .
D12.776.422.220.453.890.500 Cholesterol 7-alpha-Hydroxylase .
D12.776.422.220.453.915 Steroid Hydroxylases .
D12.776.422.220.453.915.050 Cytochrome P-450 CYP11B2 .
D12.776.422.220.453.915.099 Aromatase .
D12.776.422.220.453.915.200 Cholesterol 7-alpha-Hydroxylase .
D12.776.422.220.453.915.212 Cholesterol Side-Chain Cleavage Enzyme .
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Cytochrome P-450 Enzyme System .
CYP450 Family .
CYP450 Superfamily .
Cytochrome P-450 Enzymes .
Cytochrome P-450 Families .
Cytochrome P-450 Monooxygenase .
Cytochrome P-450 Oxygenase .
Cytochrome P-450 Superfamily .
Cytochrome P450 .
Cytochrome P450 Superfamily .
Cytochrome p450 Families .
P-450 Enzymes .
P450 Enzymes .
Cytochrome P 450 .
Cytochrome P 450 Dependent Monooxygenase .
Cytochrome P 450 Enzyme System .
Cytochrome P 450 Enzymes .
Cytochrome P 450 Families .
Cytochrome P 450 Monooxygenase .
Cytochrome P 450 Oxygenase .
Cytochrome P 450 Superfamily .
Enzymes, Cytochrome P-450 .
Enzymes, P-450 .
Enzymes, P450 .
Monooxygenase, Cytochrome P-450 .
Monooxygenase, Cytochrome P-450-Dependent .
P 450 Enzymes .
P-450 Enzymes, Cytochrome .
Superfamily, CYP450 .
Superfamily, Cytochrome P-450 .
Superfamily, Cytochrome P450 .
Cytochrome P-450 .
Cytochrome P-450-Dependent Monooxygenase .
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. .
1.00
4439776
 
Camphor 5-Monooxygenase .
CYP101 .
Camphor-5-Monooxygenase .
Cytochrome P-450 101 .
Cytochrome P-450-cam .
Cytochrome P450(cam) .
P450cam .
Camphor 5 Monooxygenase .
Cytochrome P 450 101 .
Cytochrome P 450 cam .
Cytochrome P-450(cam) .
A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site. .
0.87
0429
 
Cytochrome P-450 CYP1B1 .
Cytochrome P450 CYP1B1 .
Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 .
Cytochrome P4501B1 .
Cytochrome P 450 CYP1B1 .
P450 CYP1B1, Cytochrome .
A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. CYP1B1 has been shown to be physiologically important for FETAL DEVELOPMENT with mutations in the CYP1B1 gene resulting in congenital forms of GLAUCOMA and Peter's anomaly. .
0.85
01354
 
Steroid 21-Hydroxylase .
21-Hydroxylase .
Cytochrome P-450 21-Hydroxylase .
Cytochrome P-450 c21 .
Cytochrome P-450(c-21) .
Cytochrome P450c21 .
Progesterone 21-Hydroxylase .
Steroid-21-Hydroxylase .
21 Hydroxylase .
Cytochrome P 450 21 Hydroxylase .
Cytochrome P 450 CYP21 .
Cytochrome P 450 c21 .
P-450 c21, Cytochrome .
Progesterone 21 Hydroxylase .
Steroid 21 Hydroxylase .
Steroid 21 Monooxygenase .
Cytochrome P-450 CYP21 .
Steroid 21-Monooxygenase .
CYTOCHROME P-450(C-21) .
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). .
0.85
311661
 
Cholesterol Side-Chain Cleavage Enzyme .
20,22-Desmolase .
CYP 11A1 .
Cytochrome P450 11A1 .
Cytochrome P450scc .
20,22 Desmolase .
Cholesterol Side Chain Cleavage Enzyme .
Cytochrome P 450 CYP11A1 .
CYP11A1 .
Cholesterol Desmolase .
Cholesterol Monooxygenase (Side-Chain-Cleaving) .
Cytochrome P-450 CYP11A1 .
Cytochrome P-450(scc) .
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones. .
0.84
51832
 
Cytochrome P-450 CYP11B2 .
Aldosterone Synthase Cytochrome P-450 .
Aldosynthase .
CYP 11B2 .
Cytochrome P-450c11AS .
Cytochrome P450 11B2 .
Cytochrome P450Aldo .
P450c11AS .
Cytochrome P 450 CYP11B2 .
Cytochrome P 450c11AS .
Steroid 18 Hydroxylase .
CYP11B2 .
Aldosterone Synthase .
Steroid 18-Hydroxylase .
A mitochondrial cytochrome P450 enzyme that catalyzes the 18-hydroxylation of steroids in the presence of molecular oxygen and NADPH-specific flavoprotein. This enzyme, encoded by CYP11B2 gene, is important in the conversion of CORTICOSTERONE to 18-hydroxycorticosterone and the subsequent conversion to ALDOSTERONE. .
0.84
51028
 
Cholesterol 7-alpha-Hydroxylase .
CYP 7 .
CYP 7A .
Cholesterol 7-alpha-Monooxygenase .
Cholesterol 7alpha-Hydroxylase .
Cholesterol-7-Hydroxylase .
Cytochrome P450 7 .
Cholesterol 7 Hydroxylase .
Cholesterol 7 alpha Hydroxylase .
Cholesterol 7 alpha Monooxygenase .
Cholesterol 7alpha Hydroxylase .
Cytochrome P 450 CYP7 .
CYP7 12921 .
CYP7A .
Cytochrome P-450 CYP7 .
CHOLESTEROL 7 ALPHA-MONOOXYGENASE .
CHOLESTEROL-7-HYDROXYLASE .
A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS. .
0.84
01332
 
Aromatase .
Androstenedione Aromatase .
CYP 19 .
CYP19 Protein .
Cytochrome P450 19 .
Estrogen Synthase .
Estrogen Synthetase .
P450AROM .
Aromatase, Androstenedione .
Cytochrome P 450 CYP19 .
Protein, CYP19 .
Cytochrome P-450(AROM) .
Cytochrome P-450 CYP19 .
CYP19 .
An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system. .
0.83
455736
 
Cytochrome P-450 CYP3A .
CYP3A4 .
CYP3A5 .
Cytochrome P-450 CYP3A4 .
Cytochrome P-450 CYP3A5 .
Cytochrome P-450IIIA .
Cytochrome P450 3A .
Cytochrome P450 3A4 .
Cytochrome P450 3A5 .
Erythromycin N-Demethylase .
Taurochenodeoxycholate 6-alpha-Monooxygenase .
3A5, Cytochrome P450 .
6-alpha-Monooxygenase, Taurochenodeoxycholate .
Cytochrome P 450 CYP3A .
Cytochrome P 450 CYP3A4 .
Cytochrome P 450 CYP3A5 .
Cytochrome P 450IIIA .
Erythromycin N Demethylase .
N-Demethylase, Erythromycin .
P-450 CYP3A, Cytochrome .
P-450 CYP3A4, Cytochrome .
P-450 CYP3A5, Cytochrome .
P-450IIIA, Cytochrome .
P450 3A, Cytochrome .
P450 3A5, Cytochrome .
Taurochenodeoxycholate 6 alpha Monooxygenase .
CYP3A .
A cytochrome P-450 suptype that has specificity for a broad variety of lipophilic compounds, including STEROIDS; FATTY ACIDS; and XENOBIOTICS. This enzyme has clinical significance due to its ability to metabolize a diverse array of clinically important drugs such as CYCLOSPORINE; VERAPAMIL; and MIDAZOLAM. This enzyme also catalyzes the N-demethylation of ERYTHROMYCIN. .
0.81
57569