serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.244 Cytochromes .
D08.244.453 Cytochrome P-450 Enzyme System .
D08.244.453.005 Aryl Hydrocarbon Hydroxylases .
D08.244.453.005.500 Cytochrome P-450 CYP1B1 .
D08.244.453.005.550 Cytochrome P-450 CYP2B1 .
D08.244.453.005.575 Cytochrome P-450 CYP2B6 .
D08.244.453.005.600 Cytochrome P-450 CYP2D6 .
D08.244.453.012 Camphor 5-Monooxygenase .
D08.244.453.100 Cytochrome P450 Family 1 .
D08.244.453.100.875 Cytochrome P-450 CYP1B1 .
D08.244.453.491 Cytochrome P450 Family 2 .
D08.244.453.491.313 Cytochrome P-450 CYP2B1 .
D08.244.453.491.344 Cytochrome P-450 CYP2B6 .
D08.244.453.491.372 Cytochrome P-450 CYP2D6 .
D08.244.453.491.375 Cytochrome P-450 CYP2E1 .
D08.244.453.493 Cytochrome P450 Family 21 .
D08.244.453.493.500 Steroid 21-Hydroxylase .
D08.244.453.498 Cytochrome P450 Family 26 .
D08.244.453.498.500 Retinoic Acid 4-Hydroxylase .
D08.244.453.915 Steroid Hydroxylases .
D08.244.453.915.760 Steroid 21-Hydroxylase .
D08.811 Enzymes .
D08.811.682 Oxidoreductases .
D08.811.682.662 Oxidoreductases Acting on CH-NH Group Donors .
D08.811.682.662.582 Oxidoreductases, N-Demethylating .
D08.811.682.662.582.338 Cytochrome P-450 CYP2E1 .
D08.811.682.690 Oxygenases .
D08.811.682.690.708 Mixed Function Oxygenases .
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System .
D08.811.682.690.708.170.010 Aryl Hydrocarbon Hydroxylases .
D08.811.682.690.708.170.010.500 Cytochrome P-450 CYP1B1 .
D08.811.682.690.708.170.010.550 Cytochrome P-450 CYP2B1 .
D08.811.682.690.708.170.010.575 Cytochrome P-450 CYP2B6 .
D08.811.682.690.708.170.010.600 Cytochrome P-450 CYP2D6 .
D08.811.682.690.708.170.012 Camphor 5-Monooxygenase .
D08.811.682.690.708.170.020 Cytochrome P450 Family 1 .
D08.811.682.690.708.170.020.875 Cytochrome P-450 CYP1B1 .
D08.811.682.690.708.170.450 Cytochrome P450 Family 2 .
D08.811.682.690.708.170.450.313 Cytochrome P-450 CYP2B1 .
D08.811.682.690.708.170.450.344 Cytochrome P-450 CYP2B6 .
D08.811.682.690.708.170.450.368 Cytochrome P-450 CYP2D6 .
D08.811.682.690.708.170.450.375 Cytochrome P-450 CYP2E1 .
D08.811.682.690.708.170.463 Cytochrome P450 Family 21 .
D08.811.682.690.708.170.463.500 Steroid 21-Hydroxylase .
D08.811.682.690.708.170.485 Cytochrome P450 Family 26 .
D08.811.682.690.708.170.485.500 Retinoic Acid 4-Hydroxylase .
D08.811.682.690.708.170.915 Steroid Hydroxylases .
D08.811.682.690.708.170.915.760 Steroid 21-Hydroxylase .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.422 Hemeproteins .
D12.776.422.220 Cytochromes .
D12.776.422.220.453 Cytochrome P-450 Enzyme System .
D12.776.422.220.453.010 Aryl Hydrocarbon Hydroxylases .
D12.776.422.220.453.010.500 Cytochrome P-450 CYP1B1 .
D12.776.422.220.453.010.550 Cytochrome P-450 CYP2B1 .
D12.776.422.220.453.010.575 Cytochrome P-450 CYP2B6 .
D12.776.422.220.453.010.600 Cytochrome P-450 CYP2D6 .
D12.776.422.220.453.012 Camphor 5-Monooxygenase .
D12.776.422.220.453.100 Cytochrome P450 Family 1 .
D12.776.422.220.453.100.875 Cytochrome P-450 CYP1B1 .
D12.776.422.220.453.491 Cytochrome P450 Family 2 .
D12.776.422.220.453.491.313 Cytochrome P-450 CYP2B1 .
D12.776.422.220.453.491.344 Cytochrome P-450 CYP2B6 .
D12.776.422.220.453.491.368 Cytochrome P-450 CYP2D6 .
D12.776.422.220.453.491.375 Cytochrome P-450 CYP2E1 .
D12.776.422.220.453.493 Cytochrome P450 Family 21 .
D12.776.422.220.453.493.500 Steroid 21-Hydroxylase .
D12.776.422.220.453.498 Cytochrome P450 Family 26 .
D12.776.422.220.453.498.500 Retinoic Acid 4-Hydroxylase .
D12.776.422.220.453.915 Steroid Hydroxylases .
D12.776.422.220.453.915.760 Steroid 21-Hydroxylase .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Retinoic Acid 4-Hydroxylase .
CYP26A1 .
CYP26A1 Enzyme .
CYP26B1 .
CYP450 4-Hydroxylase .
Cytochrome P-450 26B1 .
Cytochrome P-450 CYP26B1 .
Cytochrome P450 26A1 Enzyme .
Cytochrome P450 4-Hydroxylase .
P450RAI .
RA-4-Hydroxylase .
Retinoic Acid-Metabolizing Enzyme, CYP26B1 .
CYP26B1, Cytochrome P-450 .
Cytochrome P 450 CYP26B1 .
Cytochrome P450 4 Hydroxylase .
Enzyme, CYP26A1 .
RA 4 Hydroxylase .
Retinoic Acid 4 Hydroxylase .
Retinoic Acid Metabolizing Enzyme, CYP26B1 .
A cytochrome P450 enzyme that resides in the ENDOPLASMIC RETICULUM. It catalyzes the conversion of trans-RETINOIC ACID to 4-hydroxyretinoic acid. .
1.00
0417
 
Cytochrome P-450 Enzyme System .
CYP450 Family .
CYP450 Superfamily .
Cytochrome P-450 Enzymes .
Cytochrome P-450 Families .
Cytochrome P-450 Monooxygenase .
Cytochrome P-450 Oxygenase .
Cytochrome P-450 Superfamily .
Cytochrome P450 .
Cytochrome P450 Superfamily .
Cytochrome p450 Families .
P-450 Enzymes .
P450 Enzymes .
Cytochrome P 450 .
Cytochrome P 450 Dependent Monooxygenase .
Cytochrome P 450 Enzyme System .
Cytochrome P 450 Enzymes .
Cytochrome P 450 Families .
Cytochrome P 450 Monooxygenase .
Cytochrome P 450 Oxygenase .
Cytochrome P 450 Superfamily .
Enzymes, Cytochrome P-450 .
Enzymes, P-450 .
Enzymes, P450 .
Monooxygenase, Cytochrome P-450 .
Monooxygenase, Cytochrome P-450-Dependent .
P 450 Enzymes .
P-450 Enzymes, Cytochrome .
Superfamily, CYP450 .
Superfamily, Cytochrome P-450 .
Superfamily, Cytochrome P450 .
Cytochrome P-450 .
Cytochrome P-450-Dependent Monooxygenase .
A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. .
0.67
4339776
 
Cytochrome P-450 CYP2D6 .
CYP 2D6 .
Cytochrome P450 2D6 .
Debrisoquine 4-Monooxygenase .
Imipramine 2-Hydroxylase .
Sparteine Monooxygenase .
2-Hydroxylase, Imipramine .
4-Hydroxylase, Debrisoquine .
4-Monooxygenase, Debrisoquine .
CYP2D6, Cytochrome P-450 .
Cytochrome P 450 CYP2D6 .
Debrisoquine 4 Hydroxylase .
Debrisoquine 4 Monooxygenase .
Hydroxylase, Debrisoquine .
Imipramine 2 Hydroxylase .
Monooxygenase, Sparteine .
P-450 CYP2D6, Cytochrome .
P450 2D6, Cytochrome .
CYP2D6 .
Debrisoquine Hydroxylase .
Debrisoquine 4-Hydroxylase .
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population. .
0.59
43825
 
Cytochrome P-450 CYP2B6 .
1,4-Cineole 2-exo-Monooxygenase .
CYP2B6 .
CYPIIB6 .
Cytochrome P450 2B6 .
1,4 Cineole 2 exo Monooxygenase .
2-exo-Monooxygenase, 1,4-Cineole .
CYP2B6, Cytochrome P-450 .
Cytochrome P 450 CYP2B6 .
P-450 CYP2B6, Cytochrome .
P450 2B6, Cytochrome .
A cytochrome P450 enzyme subtype that oxidizes a diverse array of XENOBIOTICS. The expression of CYP2B6 varies widely between individuals which is due to the high rate of GENETIC POLYMORPHISMS. Examples of drugs metabolized by CYP2B6 include BUPROPION; efavirenz; CYCLOPHOSPHAMIDE; and MEPERIDINE. .
0.59
1851
 
Cytochrome P-450 CYP2E1 .
CYP 2E1 .
CYP IIE1 .
CYPIIE1 .
Cytochrome P-450 (ALC) .
Cytochrome P-450 IIE1 .
Cytochrome P-450-J .
Cytochrome P450 2E1 .
N-Nitrosodimethylamine Demethylase .
4 Nitrophenol 2 Hydroxylase .
Cytochrome P 450 CYP2E1 .
Cytochrome P 450 IIE1 .
Cytochrome P 450 J .
Dimethylnitrosamine N Demethylase .
N Nitrosodimethylamine Demethylase .
CYP2E1 .
Dimethylnitrosamine N-Demethylase .
4-Nitrophenol-2-Hydroxylase .
An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include ETHANOL; INHALATION ANESTHETICS; BENZENE; ACETAMINOPHEN and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse. .
0.59
93257
 
Cytochrome P-450 CYP2B1 .
7-Benzyloxyresorufin O-Dealkylase .
7-Pentylresorufin O-Depentylase .
CYP 2B1 .
Cytochrome P450 2B1 .
7 Benzyloxyresorufin O Dealkylase .
7 Pentylresorufin O Depentylase .
Benzyloxyresorufin O Dealkylase .
Cytochrome P 450 CYP2B1 .
O-Dealkylase, Pentoxyresorufin .
Pentoxyresorufin O Dealkylase .
Benzyloxyresorufin O-Dealkylase .
BROD 20946 .
CYP2B1 .
Pentoxyresorufin O-Dealkylase .
PROD 20946 .
A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS. .
0.59
2930
 
Camphor 5-Monooxygenase .
CYP101 .
Camphor-5-Monooxygenase .
Cytochrome P-450 101 .
Cytochrome P-450-cam .
Cytochrome P450(cam) .
P450cam .
Camphor 5 Monooxygenase .
Cytochrome P 450 101 .
Cytochrome P 450 cam .
Cytochrome P-450(cam) .
A soluble cytochrome P-450 enzyme that catalyzes camphor monooxygenation in the presence of putidaredoxin, putidaredoxin reductase, and molecular oxygen. This enzyme, encoded by the CAMC gene also known as CYP101, has been crystallized from bacteria and the structure is well defined. Under anaerobic conditions, this enzyme reduces the polyhalogenated compounds bound at the camphor-binding site. .
0.58
0429
 
Cytochrome P-450 CYP1B1 .
Cytochrome P450 CYP1B1 .
Cytochrome P450, Family 1, Subfamily B, Polypeptide 1 .
Cytochrome P4501B1 .
Cytochrome P 450 CYP1B1 .
P450 CYP1B1, Cytochrome .
A cytochrome P450 aryl hydrocarbon hydroxylase that has specificity for ESTROGENS which it converts into 4-hydroxy estrogens. CYP1B1 has been shown to be physiologically important for FETAL DEVELOPMENT with mutations in the CYP1B1 gene resulting in congenital forms of GLAUCOMA and Peter's anomaly. .
0.57
01354
 
Steroid 21-Hydroxylase .
21-Hydroxylase .
Cytochrome P-450 21-Hydroxylase .
Cytochrome P-450 c21 .
Cytochrome P-450(c-21) .
Cytochrome P450c21 .
Progesterone 21-Hydroxylase .
Steroid-21-Hydroxylase .
21 Hydroxylase .
Cytochrome P 450 21 Hydroxylase .
Cytochrome P 450 CYP21 .
Cytochrome P 450 c21 .
P-450 c21, Cytochrome .
Progesterone 21 Hydroxylase .
Steroid 21 Hydroxylase .
Steroid 21 Monooxygenase .
Cytochrome P-450 CYP21 .
Steroid 21-Monooxygenase .
CYTOCHROME P-450(C-21) .
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL). .
0.56
311661