serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.455 Hydrocarbons .
D02.455.426 Hydrocarbons, Cyclic .
D02.455.426.559 Hydrocarbons, Aromatic .
D02.455.426.559.847 Polycyclic Aromatic Hydrocarbons .
D02.455.426.559.847.638 Naphthalenes .
D02.455.426.559.847.638.960 Tetrahydronaphthalenes .
D02.455.426.559.847.638.960.675 Podophyllotoxin .
D02.455.426.559.847.638.960.675.250 Etoposide .
D04 Polycyclic Compounds .
D04.615 Polycyclic Aromatic Hydrocarbons .
D04.615.638 Naphthalenes .
D04.615.638.960 Tetrahydronaphthalenes .
D04.615.638.960.675 Podophyllotoxin .
D04.615.638.960.675.250 Etoposide .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.399 Isomerases .
D08.811.399.403 DNA Topoisomerases .
D08.811.399.403.483 DNA Topoisomerases, Type I .
D08.811.399.403.741 DNA Topoisomerases, Type II .
D08.811.399.403.741.149 DNA Gyrase .
D08.811.399.403.741.224 DNA Topoisomerase IV .
D08.811.739 Recombinases .
D08.811.739.800 Transposon Resolvases .
D08.811.913 Transferases .
D08.811.913.696 Phosphotransferases .
D08.811.913.696.445 Nucleotidyltransferases .
D08.811.913.696.445.837 Transposon Resolvases .
D09 Carbohydrates .
D09.408 Glycosides .
D09.408.348 Glucosides .
D09.408.348.275 Etoposide .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.097 Bacterial Proteins .
D12.776.097.237 DNA Gyrase .
D12.776.097.256 DNA Topoisomerase IV .
D12.776.157 Carrier Proteins .
D12.776.157.687 Poly-ADP-Ribose Binding Proteins .
D12.776.157.687.375 DNA Topoisomerases, Type I .
D12.776.660 Nuclear Proteins .
D12.776.660.720 Poly-ADP-Ribose Binding Proteins .
D12.776.660.720.375 DNA Topoisomerases, Type I .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.222 DNA Repair .
G02.111.222.200 DNA End-Joining Repair .
G05 Genetic Phenomena .
G05.200 DNA Damage .
G05.200.210 DNA Breaks .
G05.200.210.230 DNA Breaks, Single-Stranded .
G05.219 DNA Repair .
G05.219.200 DNA End-Joining Repair .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
DNA Topoisomerases, Type I .
DNA Nicking-Closing Proteins .
DNA Relaxing Enzymes .
DNA Type 1 Topoisomerase .
DNA Untwisting Enzymes .
DNA Untwisting Proteins .
Topoisomerase I .
Type I DNA Topoisomerase .
DNA Nicking-Closing Protein .
DNA Relaxing Enzyme .
DNA Relaxing Protein .
DNA Topoisomerase .
DNA Topoisomerase I .
DNA Untwisting Enzyme .
DNA Untwisting Protein .
DNA Untwisting Enzymes .
DNA Topoisomerases, Type I, Eukaryotic .
DNA Topoisomerase I, Eukaryotic .
DNA Topoisomerases, Type I, Bacterial .
DNA Topoisomerase I, Bacterial .
DNA Topoisomerases, Type I, Archaeal .
DNA Untwisting Proteins .
OMEGA PROTEIN .
DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. .
1.00
114416
 
DNA Topoisomerases, Type II .
DNA Topoisomerase II alpha .
DNA Topoisomerase II beta .
DNA Type 2 Topoisomerase .
TOP2A Protein .
TOP2B Protein .
Topoisomerase II .
Topoisomerase II alpha .
Topoisomerase II beta .
Type II DNA Topoisomerase .
alpha, Topoisomerase II .
beta, Topoisomerase II .
DNA Topoisomerase (ATP-Hydrolysing) .
DNA Topoisomerase II .
DNA Topoisomerases, Type II, Eukaryotic .
DNA Topoisomerases, Type II, Bacterial .
DNA Topoisomerase II, Bacterial .
DNA Topoisomerases, Type II, Archaeal .
DNA-GYRASE .
DNA TOPOISOMERASES that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA and resolution of a knotted circular DNA duplex. .
0.73
75483
 
DNA Topoisomerase IV .
Topo IV .
Topoisomerase IV .
Topoisomerase IV Subunit A .
Topoisomerase IV Subunit B .
parC Gene Product .
parC Gene Product, Topo IV .
parE Gene Product .
parE Gene Product, Topo IV .
Topoisomerase IV, DNA .
parC Protein .
parE Protein .
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication. .
0.59
61021
 
DNA Gyrase .
DNA-Gyrase .
GyrA Protein .
GyrB Protein .
DNA Gyrase A Subunit .
DNA Gyrase B Subunit .
gyrA Protein .
gyrB Protein .
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase. .
0.57
152505
 
DNA Topoisomerases .
Topoisomerases, DNA .
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. .
0.55
3322
 
Transposon Resolvases .
TnpR Protein .
Resolvases, Transposon .
Recombinases that involved in the propagation of DNA TRANSPOSONS. They bind to transposon sequences found at two different sites along the same stretch of DNA and bring them into close proximity. The enzymes then catalyze the double strand cleavage, exchange of double strands and rejoining of DNA helices so that the DNA transposon is formed into a circular PLASMID. .
0.43
086
 
DNA End-Joining Repair .
End-Joining DNA Repair .
MMEJ DNA Repair .
Microhomology-Mediated End Joining Repair .
NHEJ DNA Repair .
Nonhomologous DNA End-Joining .
DNA End Joining Repair .
DNA End-Joining, Non-Homologous .
DNA End-Joining, Nonhomologous .
DNA Repair, End-Joining .
DNA Repair, MMEJ .
DNA Repair, NHEJ .
End Joining DNA Repair .
End-Joining Repair, DNA .
End-Joining, Non-Homologous DNA .
Microhomology Mediated End Joining Repair .
Non Homologous DNA End Joining .
Nonhomologous DNA End Joining .
Repair, DNA End-Joining .
Repair, End-Joining DNA .
Repair, MMEJ DNA .
Repair, NHEJ DNA .
Non-Homologous DNA End-Joining .
The repair of DOUBLE-STRAND DNA BREAKS by rejoining the broken ends of DNA to each other directly. .
0.42
2901
 
Etoposide .
Celltop .
Eposide .
Eposin .
Eto-GRY .
Etomedac .
Etopos .
Etoposide Pierre Fabre .
Etoposide Teva .
Etoposide, (5S)-Isomer .
Etoposide, (5a alpha)-Isomer .
Etoposide, (5a alpha,9 alpha)-Isomer .
Etoposide, alpha-D-Glucopyranosyl Isomer .
Etoposido Ferrer Farma .
Exitop .
Lastet .
NSC-141540 .
Onkoposid .
Riboposid .
Toposar .
VP 16-213 .
VP-16 .
Vepesid .
Vépéside-Sandoz .
Eto GRY .
Etoposide, alpha D Glucopyranosyl Isomer .
NSC 141540 .
NSC141540 .
Teva, Etoposide .
VP 16 .
VP 16 213 .
VP 16213 .
VP16 3939 .
Vépéside Sandoz .
alpha-D-Glucopyranosyl Isomer Etoposide .
Demethyl Epipodophyllotoxin Ethylidine Glucoside .
VP 16-213 .
VP-16 .
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. .
0.42
5815602
 
DNA Breaks, Single-Stranded .
DNA Nicks .
Single-Strand DNA Breaks .
Single-Stranded DNA Break .
Break, Single-Strand DNA .
Break, Single-Stranded DNA .
Breaks, Single-Strand DNA .
Breaks, Single-Stranded DNA .
DNA Break, Single-Strand .
DNA Break, Single-Stranded .
DNA Breaks, Single Stranded .
DNA Breaks, Single-Strand .
DNA Nick .
Nick, DNA .
Nicks, DNA .
Single Strand DNA Breaks .
Single Stranded DNA Break .
Single Stranded DNA Breaks .
Single-Strand DNA Break .
Single-Stranded DNA Breaks .
Interruptions in one of the strands of the sugar-phosphate backbone of double-stranded DNA. .
0.41
0662