Receptors, Drug. Drug Receptor . Receptor, Drug . Drug Receptors . Proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells. Drug receptors are generally thought to be receptors for some endogenous substance not otherwise specified. . 0.55
Receptors, Thyroid Hormone. DIT Receptors . Diiodotyrosine Receptor . MIT Receptors . Monoiodotyrosine Receptors . Receptors, DIT . Receptors, MIT . Receptors, Monoiodotyrosine . Receptors, T3 . Receptors, T4 . T3 Receptor . T4 Receptor . Thyroid Hormone Receptor . Thyroxine Receptor . Diiodotyrosine Receptors . Thyroid Hormone Receptors . Thyroxine Receptors . Triiodothyronine Receptors . T3 Receptors . T4 Receptors . Receptors, Diiodotyrosine . Receptors, Thyroxine . Receptors, Triiodothyronine . TR BETA . TR ALPHA . Specific high affinity binding proteins for THYROID HORMONES in target cells. They are usually found in the nucleus and regulate DNA transcription. These receptors are activated by hormones that leads to transcription, cell differentiation, and growth suppression. Thyroid hormone receptors are encoded by two genes (GENES, ERBA): erbA-alpha and erbA-beta for alpha and beta thyroid hormone receptors, respectively. . 0.53
Receptors, Death Domain. Death Receptors . Receptors, DR Family . Receptors, Death Domain Family . DR Family Receptors . Death Domain Receptors . A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. . 0.51
DCC Receptor. DCC Tumor Suppressor Protein . DCC-Netrin-1 Receptor . Deleted in Colorectal Carcinoma Protein . DCC Netrin 1 Receptor . Receptor, DCC . Receptor, DCC-Netrin-1 . A receptor for NETRIN-1 that contains four membrane distal (N-terminal) Ig-like C2 domains and six membrane proximal (C-terminal) fibronectin type III domains. It is expressed primarily in the nerve axons and differentiated intestinal cells and is required for AXON GUIDANCE, mediating axon attraction of neuronal GROWTH CONES; however, it may also trigger axon repulsion through association with the UNC5 netrin-1 receptor. DCC also induces APOPTOSIS when it is unbound from netrin-1. Deletions of the DCC gene are observed in tumor metastases and the protein is not expressed in undifferentiated COLORECTAL CARCINOMA cells. . 0.50