serw-MX  [xml]  
 


    
 DeCS Categories

D03 Heterocyclic Compounds .
D03.633 Heterocyclic Compounds, Fused-Ring .
D03.633.100 Heterocyclic Compounds, 2-Ring .
D03.633.100.531 Isoquinolines .
D03.633.100.531.205 Debrisoquin .
D08 Enzymes and Coenzymes .
D08.244 Cytochromes .
D08.244.453 Cytochrome P-450 Enzyme System .
D08.244.453.005 Aryl Hydrocarbon Hydroxylases .
D08.244.453.005.600 Cytochrome P-450 CYP2D6 .
D08.244.453.491 Cytochrome P450 Family 2 .
D08.244.453.491.372 Cytochrome P-450 CYP2D6 .
D08.811 Enzymes .
D08.811.682 Oxidoreductases .
D08.811.682.690 Oxygenases .
D08.811.682.690.708 Mixed Function Oxygenases .
D08.811.682.690.708.170 Cytochrome P-450 Enzyme System .
D08.811.682.690.708.170.010 Aryl Hydrocarbon Hydroxylases .
D08.811.682.690.708.170.010.600 Cytochrome P-450 CYP2D6 .
D08.811.682.690.708.170.450 Cytochrome P450 Family 2 .
D08.811.682.690.708.170.450.368 Cytochrome P-450 CYP2D6 .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.422 Hemeproteins .
D12.776.422.220 Cytochromes .
D12.776.422.220.453 Cytochrome P-450 Enzyme System .
D12.776.422.220.453.010 Aryl Hydrocarbon Hydroxylases .
D12.776.422.220.453.010.600 Cytochrome P-450 CYP2D6 .
D12.776.422.220.453.491 Cytochrome P450 Family 2 .
D12.776.422.220.453.491.368 Cytochrome P-450 CYP2D6 .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Debrisoquin .
Debrisoquine .
Tendor .
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. .
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Cytochrome P-450 CYP2D6 .
CYP 2D6 .
Cytochrome P450 2D6 .
Debrisoquine 4-Monooxygenase .
Imipramine 2-Hydroxylase .
Sparteine Monooxygenase .
2-Hydroxylase, Imipramine .
4-Hydroxylase, Debrisoquine .
4-Monooxygenase, Debrisoquine .
CYP2D6, Cytochrome P-450 .
Cytochrome P 450 CYP2D6 .
Debrisoquine 4 Hydroxylase .
Debrisoquine 4 Monooxygenase .
Hydroxylase, Debrisoquine .
Imipramine 2 Hydroxylase .
Monooxygenase, Sparteine .
P-450 CYP2D6, Cytochrome .
P450 2D6, Cytochrome .
CYP2D6 .
Debrisoquine Hydroxylase .
Debrisoquine 4-Hydroxylase .
A cytochrome P450 enzyme that catalyzes the hydroxylation of many drugs and environmental chemicals, such as DEBRISOQUINE; ADRENERGIC RECEPTOR ANTAGONISTS; and TRICYCLIC ANTIDEPRESSANTS. This enzyme is deficient in up to 10 percent of the Caucasian population. .
0.77