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 DeCS Categories

A08 Nervous System .
A08.186 Central Nervous System .
A08.186.854 Spinal Cord .
A08.186.854.729 Spinal Cord Ventral Horn .
A08.186.854.729.500 Anterior Horn Cells .
A08.675 Neurons .
A08.675.655 Neurons, Efferent .
A08.675.655.500 Motor Neurons .
A08.675.655.500.050 Anterior Horn Cells .
A11 Cells .
A11.671 Neurons .
A11.671.655 Neurons, Efferent .
A11.671.655.500 Motor Neurons .
A11.671.655.500.050 Anterior Horn Cells .
C10 Nervous System Diseases .
C10.228 Central Nervous System Diseases .
C10.228.854 Spinal Cord Diseases .
C10.228.854.139 Amyotrophic Lateral Sclerosis .
C10.228.854.468 Muscular Atrophy, Spinal .
C10.574 Neurodegenerative Diseases .
C10.574.562 Motor Neuron Disease .
C10.574.562.250 Amyotrophic Lateral Sclerosis .
C10.574.562.500 Muscular Atrophy, Spinal .
C10.574.950 TDP-43 Proteinopathies .
C10.574.950.050 Amyotrophic Lateral Sclerosis .
C10.668 Neuromuscular Diseases .
C10.668.467 Motor Neuron Disease .
C10.668.467.250 Amyotrophic Lateral Sclerosis .
C10.668.467.500 Muscular Atrophy, Spinal .
C18 Nutritional and Metabolic Diseases .
C18.452 Metabolic Diseases .
C18.452.845 Proteostasis Deficiencies .
C18.452.845.800 TDP-43 Proteinopathies .
C18.452.845.800.050 Amyotrophic Lateral Sclerosis .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.260 DNA-Binding Proteins .
D12.776.260.103 Basic Helix-Loop-Helix Transcription Factors .
D12.776.260.103.798 Oligodendrocyte Transcription Factor 2 .
D12.776.631 Nerve Tissue Proteins .
D12.776.631.654 Oligodendrocyte Transcription Factor 2 .
D12.776.930 Transcription Factors .
D12.776.930.125 Basic Helix-Loop-Helix Transcription Factors .
D12.776.930.125.782 Oligodendrocyte Transcription Factor 2 .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Motor Neuron Disease .
Lower Motor Neuron Disease .
Motor Neuron Disease, Familial .
Motor Neuron Disease, Secondary .
Motor System Disease .
Primary Lateral Sclerosis .
Secondary Motor Neuron Disease .
Upper Motor Neuron Disease .
Lateral Scleroses .
Lateral Scleroses, Primary .
Lateral Sclerosis, Primary .
Motor Neuron Diseases .
Motor System Diseases .
Neuron Disease, Motor .
Neuron Diseases, Motor .
Primary Lateral Scleroses .
Scleroses, Lateral .
Scleroses, Primary Lateral .
Sclerosis, Lateral .
Sclerosis, Primary Lateral .
Lateral Sclerosis .
Anterior Horn Cell Disease .
Familial Motor Neuron Disease .
Motor Neuron Disease, Lower .
Motor Neuron Disease, Upper .
Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) .
1.00
523905
 
Amyotrophic Lateral Sclerosis .
ALS (Amyotrophic Lateral Sclerosis) .
Amyotrophic Lateral Sclerosis With Dementia .
Amyotrophic Lateral Sclerosis, Guam Form .
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam .
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 .
Charcot Disease .
Dementia With Amyotrophic Lateral Sclerosis .
Gehrig's Disease .
Guam Disease .
Guam Form of Amyotrophic Lateral Sclerosis .
Lou Gehrig's Disease .
Lou-Gehrigs Disease .
Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 .
Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam .
Disease, Guam .
Disease, Lou-Gehrigs .
Gehrig Disease .
Gehrigs Disease .
Sclerosis, Amyotrophic Lateral .
Lou Gehrig Disease .
Motor Neuron Disease, Amyotrophic Lateral Sclerosis .
GEHRIG'S DISEASE .
LOU GEHRIG'S DISEASE .
A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) .
0.47
 
Motor Neurons .
Alpha Motorneurons .
Motoneurons .
Motor Neurons, Alpha .
Neurons, Alpha Motor .
Alpha Motor Neuron .
Alpha Motor Neurons .
Alpha Motorneuron .
Motoneuron .
Motor Neuron .
Motor Neuron, Alpha .
Motorneuron, Alpha .
Motorneurons, Alpha .
Neuron, Alpha Motor .
Neuron, Motor .
Neurons, Motor .
Neurons which activate MUSCLE CELLS. .
0.42
6936061
 
Muscular Atrophy, Spinal .
Adult Spinal Muscular Atrophy .
Adult-Onset Spinal Muscular Atrophy .
Amyotrophy, Neurogenic Scapuloperoneal, New England Type .
Distal Spinal Muscular Atrophy .
Hereditary Motor Neuronopathy .
Muscular Atrophy, Adult Spinal .
Myelopathic Muscular Atrophy .
Myelopathic Muscular Atrophy, Progressive .
Progressive Myelopathic Muscular Atrophy .
Progressive Proximal Myelopathic Muscular Atrophy .
Proximal Myelopathic Muscular Atrophy, Progressive .
Scapuloperoneal Spinal Muscular Atrophy .
Spinal Amyotrophy .
Spinal Muscular Atrophy, Distal .
Spinal Muscular Atrophy, Oculopharyngeal .
Spinal Muscular Atrophy, Scapuloperoneal .
Spinal Muscular Atrophy, Scapuloperoneal Form .
Adult Onset Spinal Muscular Atrophy .
Amyotrophies, Spinal .
Amyotrophy, Spinal .
Atrophies, Progressive Muscular .
Atrophy, Myelopathic Muscular .
Atrophy, Progressive Muscular .
Atrophy, Spinal Muscular .
Bulbospinal Neuronopathies .
Hereditary Motor Neuronopathies .
Motor Neuronopathies, Hereditary .
Motor Neuronopathy, Hereditary .
Muscular Atrophies, Progressive .
Muscular Atrophy, Myelopathic .
Muscular Atrophy, Progressive .
Neuronopathies, Bulbospinal .
Neuronopathies, Hereditary Motor .
Neuronopathy, Bulbospinal .
Neuronopathy, Hereditary Motor .
Progressive Muscular Atrophies .
Spinal Amyotrophies .
Progressive Muscular Atrophy .
Spinal Muscular Atrophy .
Bulbospinal Neuronopathy .
Oculopharyngeal Spinal Muscular Atrophy .
Scapuloperoneal Form of Spinal Muscular Atrophy .
MYELOPATHIC MUSCULAR ATROPHY .
A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089) .
0.42
562894
 
Anterior Horn Cells .
Anterior Horn Cell .
Anterior Horn Neuron .
Cell, Anterior Horn .
Cell, Ventral Horn .
Cells, Anterior Horn .
Cells, Ventral Horn .
Neuron, Anterior Horn .
Neuron, Ventral Horn .
Ventral Horn Cell .
Ventral Horn Neuron .
Anterior Horn Neurons .
Neurons, Anterior Horn .
Neurons, Ventral Horn .
Ventral Horn Cells .
Ventral Horn Neurons .
MOTOR NEURONS in the anterior (ventral) horn of the SPINAL CORD which project to SKELETAL MUSCLES. .
0.39
41028
 
Oligodendrocyte Transcription Factor 2 .
OLIG-2 Protein .
OLIG2 Protein .
OLIG 2 Protein .
A basic helix-loop-helix transcription factor that is required for differentiation of OLIGODENDROCYTES and motor neurons in the spinal cord, and development of somatic motor neurons in the hindbrain. .
0.38
0477