Cytochrome P-450 Enzyme System. CYP450 Family . CYP450 Superfamily . Cytochrome P-450 Enzymes . Cytochrome P-450 Families . Cytochrome P-450 Monooxygenase . Cytochrome P-450 Oxygenase . Cytochrome P-450 Superfamily . Cytochrome P450 . Cytochrome P450 Superfamily . Cytochrome p450 Families . P-450 Enzymes . P450 Enzymes . Cytochrome P 450 . Cytochrome P 450 Dependent Monooxygenase . Cytochrome P 450 Enzyme System . Cytochrome P 450 Enzymes . Cytochrome P 450 Families . Cytochrome P 450 Monooxygenase . Cytochrome P 450 Oxygenase . Cytochrome P 450 Superfamily . Enzymes, Cytochrome P-450 . Enzymes, P-450 . Enzymes, P450 . Monooxygenase, Cytochrome P-450 . Monooxygenase, Cytochrome P-450-Dependent . P 450 Enzymes . P-450 Enzymes, Cytochrome . Superfamily, CYP450 . Superfamily, Cytochrome P-450 . Superfamily, Cytochrome P450 . Cytochrome P-450 . Cytochrome P-450-Dependent Monooxygenase . A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism. . 1.00
/enzymology. /enzyme activity . /enzymes . Used with organisms, except vertebrates, and with organs and tissues. It is also used with diseases for enzymes during the course of the disease, but excludes diagnostic enzyme tests, for which "diagnosis" is used. . 0.71
Enzymes. Biocatalysts . Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified. . 0.71
