serw-MX  [xml]  

 DeCS Categories

D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.543 Membrane Proteins .
D12.776.543.750 Receptors, Cell Surface .
D12.776.543.750.690 Receptors, Death Domain .
D12.776.543.750.690.500 fas Receptor .
D12.776.543.750.705 Receptors, Immunologic .
D12.776.543.750.705.852 Receptors, Cytokine .
D12.776.543.750.705.852.760 Receptors, Tumor Necrosis Factor .
D12.776.543.750.705.852.760.195 fas Receptor .
 Synonyms & Historicals
fas Receptor .
CD95 Antigen .
Fas Cell Surface Death Receptor .
TNFRSF6 Receptor .
fas Antigen .
APO 1 Antigen .
Receptor, TNFRSF6 .
Receptor, fas .
Antigens, CD95 .
APO-1 Antigen .
CD95 Antigens .
fas Antigens .
Tumor Necrosis Factor Receptor Superfamily, Member 6 .
fas Receptors .
Receptors, fas .
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. Mutations in the CD95 gene are associated with cases of autoimmune lymphoproliferative syndrome. .
Receptors, Cell Surface .
Cell Surface Hormone Receptors .
Endogenous Substances Receptors .
Cell Surface Receptors .
Receptors, Endogenous Substances .
Hormone Receptors, Cell Surface .
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands. .
Receptors, Death Domain .
Death Receptors .
Receptors, DR Family .
Receptors, Death Domain Family .
DR Family Receptors .
Death Domain Receptors .
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. .