Amyotrophic Lateral Sclerosis. ALS (Amyotrophic Lateral Sclerosis) . Amyotrophic Lateral Sclerosis With Dementia . Amyotrophic Lateral Sclerosis, Guam Form . Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam . Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 . Charcot Disease . Dementia With Amyotrophic Lateral Sclerosis . Gehrig's Disease . Guam Disease . Guam Form of Amyotrophic Lateral Sclerosis . Lou Gehrig's Disease . Lou-Gehrigs Disease . Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 . Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam . Disease, Guam . Disease, Lou-Gehrigs . Gehrig Disease . Gehrigs Disease . Sclerosis, Amyotrophic Lateral . Lou Gehrig Disease . Motor Neuron Disease, Amyotrophic Lateral Sclerosis . GEHRIG'S DISEASE . LOU GEHRIG'S DISEASE . A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) . 1.00
Disease. Diseases . Illness . Disease Concept Evolution . A definite pathologic process with a characteristic set of signs and symptoms. It may affect the whole body or any of its parts, and its etiology, pathology, and prognosis may be known or unknown. . 0.52
