serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.913 Transferases .
D08.811.913.696 Phosphotransferases .
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) .
D08.811.913.696.620.682 Protein Kinases .
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400 Receptor Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400.009 ErbB Receptors .
D08.811.913.696.620.682.725.400.009.300 Receptor, Epidermal Growth Factor .
D12 Amino Acids, Peptides, and Proteins .
D12.644 Peptides .
D12.644.276 Intercellular Signaling Peptides and Proteins .
D12.644.276.382 EGF Family of Proteins .
D12.644.276.382.750 Transforming Growth Factor alpha .
D12.644.276.963 Transforming Growth Factors .
D12.644.276.963.360 Transforming Growth Factor alpha .
D12.776 Proteins .
D12.776.467 Intercellular Signaling Peptides and Proteins .
D12.776.467.382 EGF Family of Proteins .
D12.776.467.382.750 Transforming Growth Factor alpha .
D12.776.467.960 Transforming Growth Factors .
D12.776.467.960.360 Transforming Growth Factor alpha .
D12.776.543 Membrane Proteins .
D12.776.543.750 Receptors, Cell Surface .
D12.776.543.750.630 Receptor Protein-Tyrosine Kinases .
D12.776.543.750.630.009 ErbB Receptors .
D12.776.543.750.630.009.300 Receptor, Epidermal Growth Factor .
D12.776.543.750.750 Receptors, Peptide .
D12.776.543.750.750.360 Receptors, Gastrointestinal Hormone .
D12.776.543.750.750.360.300 Receptor, Epidermal Growth Factor .
D12.776.543.750.750.400 Receptors, Growth Factor .
D12.776.543.750.750.400.074 ErbB Receptors .
D12.776.543.750.750.400.074.300 Receptor, Epidermal Growth Factor .
D23 Biological Factors .
D23.529 Intercellular Signaling Peptides and Proteins .
D23.529.382 EGF Family of Proteins .
D23.529.382.750 Transforming Growth Factor alpha .
D23.529.960 Transforming Growth Factors .
D23.529.960.360 Transforming Growth Factor alpha .
G05 Genetic Phenomena .
G05.360 Genetic Structures .
G05.360.340 Genome .
G05.360.340.024 Genome Components .
G05.360.340.024.340 Genes .
G05.360.340.024.340.375 Genes, Neoplasm .
G05.360.340.024.340.375.500 Oncogenes .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Oncogenes .
Oncogene .
Transforming Gene .
Gene, Transforming .
Genes, Transforming .
Transforming Genes .
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of CELL PROLIFERATION such as growth factors, growth factor receptors, protein kinases, signal transducers, nuclear phosphoproteins, and transcription factors. A prefix of "v-" before oncogene symbols indicates oncogenes captured and transmitted by RETROVIRUSES; the prefix "c-" before the gene symbol of an oncogene indicates it is the cellular homolog (PROTO-ONCOGENES) of a v-oncogene. .
0.58
23014393
 
Transforming Growth Factors .
Transforming Growth Factor .
Factor, Transforming Growth .
Factors, Transforming Growth .
Growth Factor, Transforming .
Growth Factors, Transforming .
Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA. .
0.57
272360
 
Intercellular Signaling Peptides and Proteins .
Peptide Factors, Paracrine .
Growth Factors .
Paracrine Peptide Factors .
Paracrine Protein Factors .
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal. .
0.57
5823225
 
Transforming Growth Factor alpha .
TGFalpha .
Epidermal Growth Factor Related Transforming Growth Factor .
Epidermal Growth Factor-Related Transforming Growth Factor .
TGF-alpha .
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR. .
0.52
164096
 
Receptor, Epidermal Growth Factor .
Epidermal Growth Factor Receptor Kinase .
Proto-oncogene c-ErbB-1 Protein .
Receptor Tyrosine-protein Kinase erbB-1 .
Receptor, ErbB-1 .
Epidermal Growth Factor Receptor Protein Tyrosine Kinase .
ErbB-1 Receptor .
Proto oncogene c ErbB 1 Protein .
Proto-Oncogene Protein, erbB-1 .
Receptor Tyrosine protein Kinase erbB 1 .
Receptor, ErbB 1 .
Receptor, TGF alpha .
Receptor, Transforming Growth Factor alpha .
c erbB 1 Protein .
c-ErbB-1 Protein, Proto-oncogene .
erbB 1 Proto Oncogene Protein .
c-erbB-1 Protein .
EGF Receptor .
Epidermal Growth Factor Receptor .
Receptor, Transforming-Growth Factor alpha .
Urogastrone Receptor .
Receptor, TGF-alpha .
Receptor, Urogastrone .
Transforming Growth Factor alpha Receptor .
TGF-alpha Receptor .
erbB-1 Proto-Oncogene Protein .
Epidermal Growth Factor Receptor Protein-Tyrosine Kinase .
Receptor, EGF .
RECEPTORS, TRANSFORMING-GROWTH FACTOR ALPHA .
TGF-ALPHA RECEPTORS .
PROTO-ONCOGENE PROTEINS C-ERBB-1 .
EGF-URO RECEPTORS .
UROGASTRONE RECEPTORS .
RECEPTORS, TGF-ALPHA .
RECEPTORS, UROGASTRONE .
TRANSFORMING GROWTH FACTOR ALPHA RECEPTORS .
C-ERBB-1 PROTEINS .
ERBB-1 PROTO-ONCOGENE PRODUCTS .
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell. .
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