Guanylate Cyclase. Deoxyguanylate Cyclase . Guanylyl Cyclase . Inosinate Cyclase . Cyclase, Deoxyguanylate . Cyclase, Guanyl . Cyclase, Guanylate . Cyclase, Guanylyl . Cyclase, Inosinate . Guanyl Cyclase . An enzyme that catalyzes the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. It also acts on ITP and dGTP. (From Enzyme Nomenclature, 1992) EC 4.6.1.2. . 1.00
Soluble Guanylyl Cyclase. Nitric Oxide Receptor . Nitric Oxide Receptors . Nitric Oxide-Sensitive Guanylyl Cyclase . Receptor, Nitric Oxide . Soluble Guanylate Cyclase . Soluble Guanylyl Cyclase, alpha Subunit . Soluble Guanylyl Cyclase, beta Subunit . Cyclase, Soluble Guanylate . Cyclase, Soluble Guanylyl . Guanylate Cyclase, Soluble . Guanylyl Cyclase, Soluble . Nitric Oxide Sensitive Guanylyl Cyclase . Oxide Receptor, Nitric . Oxide Receptors, Nitric . A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. . 0.81
Receptors, Enterotoxin. Enterotoxin Receptor . Enterotoxin Receptors . Enterotoxin-Guanylin Receptor . Enterotoxin-Guanylin Receptors . GC-C Receptor . GC-C Receptors . Guanyl Cyclase-C Receptor . Guanyl Cyclase-C Receptors . Guanylin-Uroguanylin Receptor . Guanylin-Uroguanylin Receptors . Guanylyl Cyclase C . Heat-Stable Enterotoxin Receptor . Heat-Stable Enterotoxin Receptors . Receptor, Enterotoxin . Receptor, Guanyl Cyclase-C . Receptors, Guanyl Cyclase-C . Cyclase C, Guanylyl . Cyclase-C Receptors, Guanyl . Enterotoxin Guanylin Receptor . Enterotoxin Guanylin Receptors . Enterotoxin Receptor, Heat-Stable . Enterotoxin Receptors, Heat-Stable . GC C Receptor . GC C Receptors . Guanyl Cyclase C Receptor . Guanyl Cyclase C Receptors . Guanylin Uroguanylin Receptor . Guanylin Uroguanylin Receptors . Heat Stable Enterotoxin Receptor . Heat Stable Enterotoxin Receptors . Receptor, Enterotoxin-Guanylin . Receptor, GC-C . Receptor, Guanyl Cyclase C . Receptor, Guanylin-Uroguanylin . Receptor, Heat-Stable Enterotoxin . Receptors, Enterotoxin-Guanylin . Receptors, GC-C . Receptors, Guanyl Cyclase C . Receptors, Guanylin-Uroguanylin . Receptors, Heat-Stable Enterotoxin . Guanylate cyclase-coupled receptors that bind bacterial ENTEROTOXINS, as well as the endogenous peptides guanylin and uroguanylin. Ligand binding stimulates production of CYCLIC GMP by EPITHELIAL CELLS of the intestinal lumen, altering barrier permeability and mucus secretion. Mutations in the gene (GUCY2C) encoding this receptor are associated with some cases of hereditary diarrhea (Diarrhea 6) and MECONIUM ILEUS. . 0.78
