Soluble Guanylyl Cyclase. Nitric Oxide Receptor . Nitric Oxide Receptors . Nitric Oxide-Sensitive Guanylyl Cyclase . Receptor, Nitric Oxide . Soluble Guanylate Cyclase . Soluble Guanylyl Cyclase, alpha Subunit . Soluble Guanylyl Cyclase, beta Subunit . Cyclase, Soluble Guanylate . Cyclase, Soluble Guanylyl . Guanylate Cyclase, Soluble . Guanylyl Cyclase, Soluble . Nitric Oxide Sensitive Guanylyl Cyclase . Oxide Receptor, Nitric . Oxide Receptors, Nitric . A mammalian enzyme composed of a heterodimer of alpha and beta subunits. Each subunit consists of four domains; N-terminal HNOX domain, PAS-like domain, a coiled-coil domain, and a C-terminal catalytic domain. All four domains are homologous proteins with a similar conformation of functional domains. Soluble guanylate cyclase catalyzes the formation of cyclic GMP from GTP, and is a key enzyme of the nitric oxide signaling pathway involved in the regulation of a variety of biological and physiological processes in mammals. . 0.81