serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.739 Recombinases .
D08.811.739.500 Integrases .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.395 Glycoproteins .
D12.776.395.550 Membrane Glycoproteins .
D12.776.395.550.200 Cell Adhesion Molecules .
D12.776.395.550.200.074 CD11 Antigens .
D12.776.395.550.200.074.500 CD11a Antigen .
D12.776.543 Membrane Proteins .
D12.776.543.550 Membrane Glycoproteins .
D12.776.543.550.200 Cell Adhesion Molecules .
D12.776.543.550.200.093 CD11 Antigens .
D12.776.543.550.200.093.500 CD11a Antigen .
D12.776.543.750 Receptors, Cell Surface .
D12.776.543.750.705 Receptors, Immunologic .
D12.776.543.750.705.408 Integrins .
D12.776.543.750.705.408.100 Integrin alpha Chains .
D12.776.543.750.705.408.100.100 CD11a Antigen .
D12.776.543.750.705.408.200 Integrin beta Chains .
D23 Biological Factors .
D23.050 Antigens .
D23.050.301 Antigens, Surface .
D23.050.301.350 Cell Adhesion Molecules .
D23.050.301.350.074 CD11 Antigens .
D23.050.301.350.074.024 CD11a Antigen .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.570 Molecular Structure .
G02.111.570.080 Base Sequence .
G02.111.570.080.708 Repetitive Sequences, Nucleic Acid .
G02.111.570.080.708.330 Interspersed Repetitive Sequences .
G02.111.570.080.708.330.200 DNA Transposable Elements .
G02.111.570.080.708.330.200.500 Integrons .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Integrins .
Receptors, Cell-Adhesion Protein .
Cell-Adhesion Molecule Receptors .
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation. .
1.00
9914188
 
Integrin beta Chains .
Integrin beta Subunits .
Integrins, beta .
beta Chains, Integrin .
beta Integrins .
Integrin beta chains combine with integrin alpha chains to form heterodimeric cell surface receptors. Integrins have traditionally been classified into functional groups based on the identity of one of three beta chains present in the heterodimer. The beta chain is necessary and sufficient for integrin-dependent signaling. Its short cytoplasmic tail contains sequences critical for inside-out signaling. .
0.79
2909
 
Integrin alpha Chains .
Integrin alpha Subunits .
Integrins, alpha .
alpha Chains, Integrin .
alpha Integrins .
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4. .
0.77
11189
 
Integrons .
Integron .
DNA elements that include the component genes and insertion site for a site-specific recombination system that enables them to capture mobile gene cassettes. .
0.73
311450
 
Integrases .
Integrase .
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA. .
0.71
95862
 
CD11a Antigen .
Integrin alphaL .
Antigen, CD11a .
alphaL, Integrin .
Antigens, CD11a .
CD11a Antigens .
An alpha-integrin subunit found on lymphocytes, granulocytes, macrophages and monocytes. It combines with the integrin beta2 subunit (CD18 ANTIGEN) to form LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1. .
0.71
0344