Sulindac. Aclin . Apo-Sulin . Arthrobid . Arthrocine . Chibret . Clinoril . Copal . Kenalin . Klinoril . MK-231 . Novo-Sundac . Nu-Sulindac . Sulindal . Apo Sulin . MK 231 . MK231 . Novo Sundac . Nu Sulindac . A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects. . 0.69
Valinomycin. A cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and related to the enniatins. It is composed of 3 moles each of L-valine, D-alpha-hydroxyisovaleric acid, D-valine, and L-lactic acid linked alternately to form a 36-membered ring. (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies. . 0.51
Dactinomycin. Cosmegen . Cosmegen Lyovac . Lyovac-Cosmegen . Lyovac Cosmegen . Lyovac, Cosmegen . LyovacCosmegen . Actinomycin D . Meractinomycin . Actinomycin . A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) . 0.50
Spectinomycin. Adspec . Ferkel Spectam . Kempi . Prospec . Salmosan-T . Spectam . Spectinomycin Dihydrochloride, Anhydrous . Spectinomycin Dihydrochloride, Pentahydrate . Spectinomycin Hydrochloride . Stanilo . Trobicin . Anhydrous Spectinomycin Dihydrochloride . Salmosan T . Spectam, Ferkel . Actinospectacin . An antibiotic produced by Streptomyces spectabilis. It is active against gram-negative bacteria and used for the treatment of GONORRHEA. . 0.46
Echinomycin. NSC-526417 . NSC 526417 . NSC526417 . Quinomycin A . A cytotoxic polypeptide quinoxaline antibiotic isolated from Streptomyces echinatus that binds to DNA and inhibits RNA synthesis. . 0.44
Klinefelter Syndrome. 48,XXYY Syndrome . 49,XXXXY Syndrome . Klinefelter Syndrome, Variants . Klinefelter's Syndrome . XXXY Males . XXY Syndrome . XXY Trisomy . Xxyy Syndrome . Klinefelter Syndromes . Klinefelter Syndromes, Variants . Klinefelters Syndrome . Syndrome, Klinefelter . Syndrome, Klinefelter's . Syndrome, Variants Klinefelter . Syndrome, XXY . Syndrome, Xxyy . Syndromes, Klinefelter . Syndromes, Variants Klinefelter . Syndromes, XXY . Syndromes, Xxyy . Trisomies, XXY . Trisomy, XXY . XXXY Male . XXY Syndromes . XXY Trisomies . Xxyy Syndromes . Klinefelter's Syndrome . A form of male HYPOGONADISM, characterized by the presence of an extra X CHROMOSOME, small TESTES, seminiferous tubule dysgenesis, elevated levels of GONADOTROPINS, low serum TESTOSTERONE, underdeveloped secondary sex characteristics, and male infertility (INFERTILITY, MALE). Patients tend to have long legs and a slim, tall stature. GYNECOMASTIA is present in many of the patients. The classic form has the karyotype 47,XXY. Several karyotype variants include 48,XXYY; 48,XXXY; 49,XXXXY, and mosaic patterns ( 46,XY/47,XXY; 47,XXY/48,XXXY, etc.). . 0.44
