Pyrin. MEFV Protein . Marenostrin . Mediterranean Fever Protein . TRIM20 Protein . A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER. . 1.00
Diet, Mediterranean. Diets, Mediterranean . Mediterranean Diets . Mediterranean Diet . A diet typical of the Mediterranean region characterized by a pattern high in fruits and vegetables, EDIBLE GRAIN and bread, potatoes, poultry, beans, nuts, olive oil and fish while low in red meat and dairy and moderate in alcohol consumption. . 0.57
beta-Thalassemia. Erythroblastic Anemia . Mediterranean Anemia . Microcytemia, beta Type . Thalassemia Intermedia . Thalassemia Major (beta-Thalassemia Major) . Thalassemia Minor (beta-Thalassemia Minor) . Thalassemia, beta Type . beta Thalassemia . Anemia, Cooley . Anemia, Cooleys . Anemias, Erythroblastic . Anemias, Mediterranean . Cooley's Anemia . Disease, Hemoglobin F . Intermedia, Thalassemia . Intermedias, Thalassemia . Major, Thalassemia (beta-Thalassemia Major) . Majors, Thalassemia (beta-Thalassemia Major) . Mediterranean Anemias . Microcytemias, beta Type . Minor, Thalassemia (beta-Thalassemia Minor) . Minors, Thalassemia (beta-Thalassemia Minor) . Thalassemia Intermedias . Thalassemia Major (beta Thalassemia Major) . Thalassemia Majors (beta-Thalassemia Major) . Thalassemia Minor (beta Thalassemia Minor) . Thalassemia Minors (beta-Thalassemia Minor) . Thalassemia, beta . Thalassemias, beta . Thalassemias, beta Type . Type Microcytemia, beta . Type Microcytemias, beta . Type Thalassemia, beta . Type Thalassemias, beta . beta Thalassemias . beta Type Microcytemia . beta Type Microcytemias . beta Type Thalassemia . beta Type Thalassemias . Anemia, Cooley's . Anemia, Erythroblastic . Anemia, Mediterranean . Hemoglobin F Disease . Thalassemia Major . Thalassemia Minor . A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent. . 0.57
