serw-MX  [xml]  

 DeCS Categories

D02 Organic Chemicals .
D02.455 Hydrocarbons .
D02.455.526 Hydrocarbons, Halogenated .
D02.455.526.728 Mustard Compounds .
D02.455.526.728.650 Nitrogen Mustard Compounds .
D02.455.526.728.650.156 Chlorambucil .
D02.455.526.728.650.156.700 Prednimustine .
D02.455.526.728.650.463 Mannomustine .
D02.455.526.728.650.913 Uracil Mustard .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.097 Azirines .
D03.383.097.217 Aziridines .
D03.383.097.217.900 Triaziquone .
D03.383.742 Pyrimidines .
D03.383.742.698 Pyrimidinones .
D03.383.742.698.875 Uracil .
D03.383.742.698.875.949 Uracil Mustard .
D04 Polycyclic Compounds .
D04.210 Fused-Ring Compounds .
D04.210.500 Steroids .
D04.210.500.745 Pregnanes .
D04.210.500.745.432 Pregnadienes .
D04.210.500.745.432.769 Pregnadienetriols .
D04.210.500.745.432.769.795 Prednisolone .
D04.210.500.745.432.769.795.700 Prednimustine .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
 Synonyms & Historicals
Mannomustine .
Decranol .
Degranol .
Mannitlost .
Mannitol Mustard .
Mustard, Mannitol .
Mustard, Mannitol Nitrogen .
Nitrogen Mustard, Mannitol .
Mannitol Nitrogen Mustard .
Nitrogen mustard derivative alkylating agent used as antineoplastic. It causes severe bone marrow depression and is a powerful vesicant. .
Uracil Mustard .
5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione .
Mustard, Uracil .
Uramustine .
Nitrogen mustard derivative of URACIL. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. .
Nitrogen Mustard Compounds .
Compounds, Nitrogen Mustard .
Mustard Compounds, Nitrogen .
A group of alkylating agents derived from mustard gas, with the sulfur replaced by nitrogen. They were formerly used as toxicants and vesicants, but now function as antineoplastic agents. These compounds are also powerful mutagens, teratogens, immunosuppressants, and carcinogens. .
Prednimustine .
Leo-1031 .
NSC-134087 .
Sterecyt .
Stereocyt .
Stéréocyt .
Leo 1031 .
Leo1031 .
NSC 134087 .
NSC134087 .
Ester of CHLORAMBUCIL and PREDNISOLONE used as a combination alkylating agent and synthetic steroid to treat various leukemias and other neoplasms. It causes gastrointestinal and bone marrow toxicity. .
Alkylating Agents .
Alkylators .
Agents, Alkylating .
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. .
Triaziquone .
2,3,5-Tris(ethyleneimine)benzoquinone .
Trenimon .
Alkylating antineoplastic agent used mainly for ovarian tumors. It is toxic to skin, gastrointestinal tract, bone marrow and kidneys. .
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .