Leptin. Ob Gene Product . Obese Gene Product . Gene Product, Ob . Gene Product, Obese . Ob Protein . Obese Protein . A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage. . 1.00
Obesity. A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). . 0.63
Ghrelin. Appetite-Regulating Hormone . GHRL Protein . Gastric MLTRP . Ghrelin Precursor . Ghrelin-Obestatin Preprohormone . Motilin-Related Peptide . Motilin-Related Peptide Precursor . Obestatin . PpMTLRP . Ppghrelin . Appetite Regulating Hormone . Ghrelin Obestatin Preprohormone . Motilin Related Peptide . Motilin Related Peptide Precursor . Peptide Precursor, Motilin-Related . Precursor, Ghrelin . Precursor, Motilin-Related Peptide . A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin. . 0.60
Proteins. Protein Gene Products . Proteins, Gene . Gene Proteins . Gene Products, Protein . GENE PRODUCTS . Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. . 0.54