Proteostasis Deficiencies. Protein Folding Diseases . Protein Folding Disorders . Protein Misfolding Diseases . Proteostasis Dysfunctions . Deficiencies, Proteostasis . Deficiency, Proteostasis . Disease, Protein Folding . Disease, Protein Misfolding . Diseases, Protein Folding . Diseases, Protein Misfolding . Disorder, Protein Folding . Disorder, Protein Misfolding . Disorders, Protein Folding . Disorders, Protein Misfolding . Dysfunction, Proteostasis . Dysfunctions, Proteostasis . Folding Disease, Protein . Folding Diseases, Protein . Folding Disorder, Protein . Folding Disorders, Protein . Misfolding Disease, Protein . Misfolding Diseases, Protein . Misfolding Disorder, Protein . Misfolding Disorders, Protein . Protein Folding Disease . Protein Folding Disorder . Protein Misfolding Disease . Protein Misfolding Disorder . Proteostasis Deficiency . Proteostasis Dysfunction . Protein Misfolding Disorders . Disorders caused by imbalances in the PROTEIN HOMEOSTASIS network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins. . 1.00
Protein Deficiency. Deficiency, Protein . Deficiencies, Protein . Protein Deficiencies . Protein Malnutrition . A nutritional condition produced by a deficiency of proteins in the diet, characterized by adaptive enzyme changes in the liver, increase in amino acid synthetases, and diminution of urea formation, thus conserving nitrogen and reducing its loss in the urine. Growth, immune response, repair, and production of enzymes and hormones are all impaired in severe protein deficiency. Protein deficiency may also arise in the face of adequate protein intake if the protein is of poor quality (i.e., the content of one or more amino acids is inadequate and thus becomes the limiting factor in protein utilization). (From Merck Manual, 16th ed; Harrison's Principles of Internal Medicine, 12th ed, p406) . 0.81
Protein S Deficiency. Deficiency, Protein S . Hereditary Thrombophilia Due To Protein S Deficiency . Deficiencies, Protein S . Protein S Deficiencies . An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523) . 0.68
