serw-MX  [xml]  
 


    
 DeCS Categories

C16 Congenital, Hereditary, and Neonatal Diseases and Abnormalities .
C16.320 Genetic Diseases, Inborn .
C16.320.565 Metabolism, Inborn Errors .
C16.320.565.798 Purine-Pyrimidine Metabolism, Inborn Errors .
C16.320.565.798.183 Dihydropyrimidine Dehydrogenase Deficiency .
C18 Nutritional and Metabolic Diseases .
C18.452 Metabolic Diseases .
C18.452.648 Metabolism, Inborn Errors .
C18.452.648.798 Purine-Pyrimidine Metabolism, Inborn Errors .
C18.452.648.798.183 Dihydropyrimidine Dehydrogenase Deficiency .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.725 Pyridines .
D03.383.725.791 Pyridones .
D03.383.742 Pyrimidines .
D03.383.742.686 Pyrimidine Nucleotides .
D03.383.742.686.600 Pyrimidine Dimers .
D03.383.742.698 Pyrimidinones .
D03.633 Heterocyclic Compounds, Fused-Ring .
D03.633.100 Heterocyclic Compounds, 2-Ring .
D03.633.100.733 Pteridines .
D13 Nucleic Acids, Nucleotides, and Nucleosides .
D13.695 Nucleotides .
D13.695.578 Polynucleotides .
D13.695.578.424 Oligonucleotides .
D13.695.578.424.600 Pyrimidine Dimers .
D13.695.740 Pyrimidine Nucleotides .
D13.695.740.600 Pyrimidine Dimers .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Pyrimidines .
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates. .
1.00
10738441
 
Pyrimidinones .
Pyrimidones .
Heterocyclic compounds known as 2-pyrimidones (or 2-hydroxypyrimidines) and 4-pyrimidones (or 4-hydroxypyrimidines) with the general formula C4H4N2O. .
0.88
104589
 
Pyridines .
Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES. .
0.82
4747228
 
Pteridines .
Pteridinones .
Pyrazinopyrimidines .
Compounds based on pyrazino[2,3-d]pyrimidine which is a pyrimidine fused to a pyrazine, containing four NITROGEN atoms. .
0.78
22431
 
Pyrimidine Dimers .
Cyclobutane-Pyrimidine Dimers .
Cytosine-Thymine Dimers .
Thymine-Cyclobutane Dimer .
Thymine-Thymine Cyclobutane Dimer .
Cyclobutane Dimer, Thymine-Thymine .
Cyclobutane Pyrimidine Dimers .
Cytosine Thymine Dimers .
Dimer, Thymine-Cyclobutane .
Dimer, Thymine-Thymine Cyclobutane .
Dimers, Cyclobutane-Pyrimidine .
Dimers, Cytosine-Thymine .
Dimers, Pyrimidine .
Dimers, Thymine .
Thymine Cyclobutane Dimer .
Thymine Thymine Cyclobutane Dimer .
Thymine Dimers .
Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION. .
0.73
72286
 
Pyridones .
Pyridinones .
Pyridine derivatives with one or more keto groups on the ring. .
0.70
126739
 
Dihydropyrimidine Dehydrogenase Deficiency .
DPD Deficiency .
Dihydropyrimidinuria .
Familial Pyrimidemia .
Familial Pyrimidinemia .
Hereditary Thymine-Uraciluria .
Pyrimidinemia, Familial .
Thymine-Uraciluria, Hereditary .
DPD Deficiencies .
Deficiencies, DPD .
Deficiencies, Dihydropyrimidine Dehydrogenase .
Deficiency, DPD .
Deficiency, Dihydropyrimidine Dehydrogenase .
Dehydrogenase Deficiencies, Dihydropyrimidine .
Dehydrogenase Deficiency, Dihydropyrimidine .
Dihydropyrimidine Dehydrogenase Deficiencies .
Dihydropyrimidinurias .
Familial Pyrimidemias .
Familial Pyrimidinemias .
Hereditary Thymine Uraciluria .
Hereditary Thymine-Uracilurias .
Pyrimidemia, Familial .
Pyrimidemias, Familial .
Pyrimidinemias, Familial .
Thymine Uraciluria, Hereditary .
Thymine-Uracilurias, Hereditary .
An autosomal recessive disorder affecting DIHYDROPYRIMIDINE DEHYDROGENASE and causing familial pyrimidinemia. It is characterized by thymine-uraciluria in homozygous deficient patients. Even a partial deficiency in the enzyme leaves individuals at risk for developing severe 5-FLUOROURACIL-associated toxicity. .
0.68
0124