serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.913 Transferases .
D08.811.913.696 Phosphotransferases .
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) .
D08.811.913.696.620.682 Protein Kinases .
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400 Receptor Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400.005 Discoidin Domain Receptors .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.543 Membrane Proteins .
D12.776.543.750 Receptors, Cell Surface .
D12.776.543.750.630 Receptor Protein-Tyrosine Kinases .
D12.776.543.750.630.005 Discoidin Domain Receptors .
D12.776.543.750.685 Receptors, Collagen .
D12.776.543.750.685.050 Discoidin Domain Receptors .
D12.776.543.750.690 Receptors, Death Domain .
D12.776.543.750.705 Receptors, Immunologic .
D12.776.543.750.705.880 Receptors, Mitogen .
D12.776.543.750.705.880.300 Discoidin Domain Receptors .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.570 Molecular Structure .
G02.111.570.820 Molecular Conformation .
G02.111.570.820.709 Protein Conformation .
G02.111.570.820.709.275 Protein Structural Elements .
G02.111.570.820.709.275.750 Protein Domains .
G02.111.570.820.709.275.750.500 Protein Interaction Domains and Motifs .
G02.111.570.820.709.275.750.500.395 Death Domain Superfamily .
G02.111.570.820.709.275.750.500.395.500 Death Domain .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Receptors, Death Domain .
Death Receptors .
Receptors, DR Family .
Receptors, Death Domain Family .
DR Family Receptors .
Death Domain Receptors .
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. The conserved domain is referred to as a DEATH DOMAIN due to the fact that many of these receptors are involved in APOPTOSIS signaling pathways. Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. .
1.00
3609
 
Death Domain .
Death Domains .
A conserved protein interaction domain of the death domain superfamily that is structurally similar to the DEATH EFFECTOR DOMAIN and CASPASE RECRUITMENT DOMAIN. Death domains bind each other to form oligomers and occur on DEATH DOMAIN RECEPTORS, where they are required for APOPTOSIS signaling and non-apoptotic functions. .
0.69
10
 
Death Domain Superfamily .
Death-Like Domain .
Death-Like Domains .
Death Domain Superfamilies .
Death Like Domain .
Death Like Domains .
Domain Superfamilies, Death .
Domain Superfamily, Death .
Superfamilies, Death Domain .
Superfamily, Death Domain .
A family of structurally-related protein interaction domains characterized by 6-helical closed bundle fold, with Greek key topology and an internal pseudo two-fold symmetry. Death-like domains occur in many proteins that are essential for APOPTOSIS, including CASPASE RECRUITMENT DOMAIN CONTAINING PROTEINS and DEATH DOMAIN RECEPTORS. .
0.63
00
 
Discoidin Domain Receptors .
DDR Proteins .
Discoidin Domain Receptor .
Proteins, DDR .
Receptor, Discoidin Domain .
Receptors, Discoidin Domain .
Receptor tyrosine kinases that bind COLLAGENS. They are characterized by the presence of extracellular DISCOIDIN DOMAINS that activate SIGNAL TRANSDUCTION PATHWAYS in response to collagen binding. They may also be cleaved by MATRIX METALLOPROTEINASES to mediate cell interactions with the EXTRACELLULAR MATRIX. .
0.61
0274