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 DeCS Categories

D02 Organic Chemicals .
D02.241 Carboxylic Acids .
D02.241.081 Acids, Acyclic .
D02.241.081.337 Dicarboxylic Acids .
D02.241.081.337.351 Glutarates .
D02.241.081.337.351.550 Meglutol .
D02.455 Hydrocarbons .
D02.455.426 Hydrocarbons, Cyclic .
D02.455.426.559 Hydrocarbons, Aromatic .
D02.455.426.559.847 Polycyclic Aromatic Hydrocarbons .
D02.455.426.559.847.638 Naphthalenes .
D02.455.426.559.847.638.400 Lovastatin .
D04 Polycyclic Compounds .
D04.615 Polycyclic Aromatic Hydrocarbons .
D04.615.638 Naphthalenes .
D04.615.638.400 Lovastatin .
D08 Enzymes and Coenzymes .
D08.211 Coenzymes .
D08.811 Enzymes .
D08.811.399 Isomerases .
D08.811.399.520 Intramolecular Transferases .
D08.811.399.520.250 Chorismate Mutase .
D08.811.399.520.250.750 Prephenate Dehydrogenase .
D08.811.682 Oxidoreductases .
D08.811.682.047 Alcohol Oxidoreductases .
D08.811.682.047.436 Hydroxysteroid Dehydrogenases .
D08.811.682.047.436.174 11-beta-Hydroxysteroid Dehydrogenases .
D08.811.682.047.820 NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases .
D08.811.682.047.820.100 11-beta-Hydroxysteroid Dehydrogenases .
D08.811.682.047.820.150 3-Hydroxyacyl CoA Dehydrogenases .
D08.811.682.047.820.150.415 Hydroxymethylglutaryl CoA Reductases .
D08.811.682.047.820.150.415.250 Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent .
D08.811.682.047.820.150.415.750 Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent .
D08.811.682.655 Nitroreductases .
D08.811.682.655.500 Nitrate Reductases .
D08.811.682.655.500.249 Nitrate Reductase (NAD(P)H) .
D08.811.682.660 Oxidoreductases Acting on CH-CH Group Donors .
D08.811.682.660.500 Prephenate Dehydrogenase .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.157 Carrier Proteins .
D12.776.157.427 Iron-Binding Proteins .
D12.776.157.427.374 Nonheme Iron Proteins .
D12.776.157.427.374.375 Iron-Sulfur Proteins .
D12.776.157.427.374.375.977 Nitrate Reductase (NAD(P)H) .
D12.776.331 Flavoproteins .
D12.776.331.901 Nitrate Reductase (NAD(P)H) .
D12.776.556 Metalloproteins .
D12.776.556.579 Iron-Binding Proteins .
D12.776.556.579.374 Nonheme Iron Proteins .
D12.776.556.579.374.375 Iron-Sulfur Proteins .
D12.776.556.579.374.375.977 Nitrate Reductase (NAD(P)H) .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent .
3-Hydroxy-3-methylglutaryl-coenzyme A reductase, NADP-dependent .
HMG CoA-Reductases, NADP-Dependent .
Hydroxymethylglutaryl-Coenzyme A Reductase (NADP) .
3 Hydroxy 3 methylglutaryl coenzyme A reductase, NADP dependent .
CoA-Reductases, NADP-Dependent HMG .
HMG CoA Reductases, NADP Dependent .
NADP-Dependent HMG CoA-Reductases .
NADP-dependent Hydroxymethylglutaryl-CoA-Reductases .
Hydroxymethylglutaryl-CoA-Reductase (NADP) .
Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. In liver enzymes of this class are involved in cholesterol biosynthesis. .
1.00
 
Meglutol .
3-Hydroxy-3-methylpentanedioic Acid .
beta-Hydroxy-beta-Methylglutarate .
3 Hydroxy 3 methylglutaric Acid .
3 Hydroxy 3 methylpentanedioic Acid .
Acid, 3-Hydroxy-3-methylglutaric .
Acid, 3-Hydroxy-3-methylpentanedioic .
beta Hydroxy beta Methylglutarate .
3-Hydroxy-3-methylglutaric Acid .
An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic steps involved in the conversion of acetate to hydroxymethylglutaryl coenzyme A as well as inhibiting the activity of HYDROXYMETHYLGLUTARYL COA REDUCTASES which is the rate limiting enzyme in the biosynthesis of cholesterol. .
0.43
 
11-beta-Hydroxysteroid Dehydrogenases .
11 beta-Hydroxysteroid Dehydrogenase .
11-Hydroxysteroid Dehydrogenase .
11B-Hydroxysteroid Dehydrogenase .
11beta-Hydroxysteroid Dehydrogenase .
Corticosteroid 11-Oxidoreductase .
Corticosteroid 11-Reductase .
Cortisone 11-Oxoreductase .
11 Hydroxysteroid Dehydrogenase .
11 beta Hydroxysteroid Dehydrogenase .
11 beta Hydroxysteroid Dehydrogenases .
11-Oxidoreductase, Corticosteroid .
11-Oxoreductase, Cortisone .
11-Reductase, Corticosteroid .
11B Hydroxysteroid Dehydrogenase .
11beta Hydroxysteroid Dehydrogenase .
Corticosteroid 11 Oxidoreductase .
Corticosteroid 11 Reductase .
Cortisone 11 Oxoreductase .
Dehydrogenase, 11 beta-Hydroxysteroid .
Dehydrogenase, 11-Hydroxysteroid .
Dehydrogenase, 11B-Hydroxysteroid .
Dehydrogenase, 11beta-Hydroxysteroid .
Dehydrogenases, 11-beta-Hydroxysteroid .
beta-Hydroxysteroid Dehydrogenase, 11 .
Hydroxysteroid dehydrogenases that catalyzes the reversible conversion of CORTISOL to the inactive metabolite CORTISONE. Enzymes in this class can utilize either NAD or NADP as cofactors. .
0.41
 
Hydroxymethylglutaryl-CoA Reductases, NAD-Dependent .
3-Hydroxy-3-methylglutaryl CoA-Reductase, NAD-Dependent .
HMG CoA Reductase, NAD-Dependent .
Hydroxymethylglutaryl CoA Reductase, NAD-Dependent .
CoA-Reductase, NAD-Dependent 3-Hydroxy-3-methylglutaryl .
HMG CoA Reductase, NAD Dependent .
HMG CoA Reductases, NAD Dependent .
Hydroxymethylglutaryl CoA Reductase, NAD Dependent .
NAD-Dependent 3-Hydroxy-3-methylglutaryl CoA-Reductase .
NAD-Dependent Hydroxymethylglutaryl-CoA Reductases .
HMG CoA Reductases, NAD-Dependent .
Specific hydroxymethylglutaryl CoA reductases that utilize the cofactor NAD. This class of enzymes performs a catabolic role in microorganisms such as Pseudomonas mevalonii where it oxidatively acetylates MEVALONIC ACID to form 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A and NADH. .
0.39
 
Lovastatin .
6-Methylcompactin .
Lovastatin, (1 alpha(S*))-Isomer .
MK-803 .
Mevacor .
Monacolin K .
1 alpha-Isomer Lovastatin .
6 Methylcompactin .
Lovastatin, 1 alpha Isomer .
MK 803 .
MK803 .
alpha-Isomer Lovastatin, 1 .
Lovastatin, 1 alpha-Isomer .
Mevinolin .
A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. .
0.38
 
Nitrate Reductase (NAD(P)H) .
Assimilatory NAD(P)H Nitrate Reductase .
Bi-Specific NAD(P)H Nitrate Reductase .
NAD(P)H Bispecific Nitrate Reductase .
NAD(P)H Nitrate Reductase .
NAD(P)H-Nitrate Reductase .
Nitrate Reductase (Reduced Nicotinamide Adenine Dinucleotide (Phosphate)) .
Nitrate Reductase NAD(P)H .
Nitrite:NAD(P)+ Oxidoreductase .
An iron-sulfur and MOLYBDENUM containing FLAVOPROTEIN that catalyzes the oxidation of nitrite to nitrate. This enzyme can use either NAD or NADP as cofactors. It is a key enzyme that is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. This enzyme was formerly classified as EC 1.6.6.2. .
0.36
 
Prephenate Dehydrogenase .
Chorismate Mutase Prephenate Dehydrogenase .
Dehydrogenase, Chorismate Mutase-Prephenate .
Dehydrogenase, Prephenate .
Mutase-Prephenate Dehydrogenase, Chorismate .
Chorismate Mutase-Prephenate Dehydrogenase .
An enzyme that catalyzes the conversion of prephenate to p-hydroxyphenylpyruvate in the presence of NAD. In the enteric bacteria, this enzyme also possesses chorismate mutase activity, thereby catalyzing the first two steps in the biosynthesis of tyrosine. EC 1.3.1.12. .
0.35
 
3-Hydroxyacyl CoA Dehydrogenases .
3 Hydroxyacyl CoA Dehydrogenases .
CoA Dehydrogenases, 3-Hydroxyacyl .
Dehydrogenases, 3-Hydroxyacyl CoA .
Dehydrogenases, beta-Hydroxyacyl .
beta Hydroxyacyl Dehydrogenases .
beta-Hydroxyacyl Dehydrogenases .
Enzymes that reversibly catalyze the oxidation of a 3-hydroxyacyl CoA to 3-ketoacyl CoA in the presence of NAD. They are key enzymes in the oxidation of fatty acids and in mitochondrial fatty acid synthesis. .
0.34
 
Coenzymes .
Cofactors, Enzyme .
Enzyme Cofactors .
Small molecules that are required for the catalytic function of ENZYMES. Many VITAMINS are coenzymes. .
0.34