TDP-43 Proteinopathies. Proteinopathies, TDP-43 . Proteinopathy, TDP-43 . TDP 43 Proteinopathies . TDP-43 Proteinopathy . Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease. . 1.00
GAP-43 Protein. GAP43 Protein . Phosphoprotein B-50 . Phosphoprotein F1 . Phosphoprotein pp46 . B 50 Protein . GAP 43 Protein . Growth Associated Protein 43 . Nerve Growth Cone Membrane Protein GAP 43 . Phosphoprotein B 50 . B-50 Protein . Nerve Growth Cone Membrane Protein GAP-43 . GAP-43 . Neuromodulin . Growth-Associated Protein 43 . A nervous tissue specific protein which is highly expressed in NEURONS during development and NERVE REGENERATION. It has been implicated in neurite outgrowth, long-term potentiation, SIGNAL TRANSDUCTION, and NEUROTRANSMITTER release. (From Neurotoxicology 1994;15(1):41-7) It is also a substrate of PROTEIN KINASE C. . 0.53
