TGF-beta Superfamily Proteins. Transforming Growth Factor beta Superfamily Proteins . Superfamily Proteins, TGF-beta . TGF beta Superfamily Proteins . A large family of cell regulatory proteins which are structurally related to TRANSFORMING GROWTH FACTOR BETA. The superfamily is subdivided into at least three related protein families: BONE MORPHOGENETIC PROTEINS; GROWTH DIFFERENTIATION FACTORS; and TRANSFORMING GROWTH FACTORS. . 1.00
Transforming Growth Factor beta. Milk Growth Factor . TGFbeta . Bone Derived Transforming Growth Factor . Factor, Milk Growth . Growth Factor, Milk . Bone-Derived Transforming Growth Factor . Platelet Transforming Growth Factor . TGF-beta . GLIOBLASTOMA-DERIVED T-CELL SUPPRESSOR FACTOR . POLYERGIN . SUPPRESSOR FACTOR, T-CELL, GLIOBLASTOMA-DERIVED . A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins. . 0.63
Transforming Growth Factor beta1. TGF-beta-1 . TGF-beta1 Latency-Associated Protein . TGF-beta1LAP . Transforming Growth Factor beta 1 Latency Associated Peptide . Transforming Growth Factor beta I . Latency-Associated Protein, TGF-beta1 . TGF beta 1 . TGF beta1 Latency Associated Protein . TGF beta1LAP . TGF-beta1 . A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME. . 0.59
Transforming Growth Factor beta2. BSC-1 Cell Growth Inhibitor . Cartilage-Inducing Factor-B . Glioblastoma-Derived T-Cell Suppressor Factor . Polyergin . Suppressor Factor, T-Cell, Glioblastoma-Derived . TGF-beta-2 . TGF-beta2 Latency-Associated Protein . TGF-beta2LAP . Transforming Growth Factor beta 2 Latency Associated Peptide . BSC 1 Cell Growth Inhibitor . Cartilage Inducing Factor B . Glioblastoma Derived T Cell Suppressor Factor . Latency-Associated Protein, TGF-beta2 . TGF beta2 Latency Associated Protein . TGF beta2LAP . TGF-beta2 . A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. . 0.58
Transforming Growth Factor beta3. TGF-beta-3 . TGF-beta3 Latency-Associated Protein . TGF-beta3LAP . TGFB3 . Transforming Growth Factor beta 3 Latency Associated Peptide . Latency-Associated Protein, TGF-beta3 . TGF beta 3 . TGF beta3 . TGF beta3 Latency Associated Protein . TGF-beta3 . A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. . 0.58
Latent TGF-beta Binding Proteins. Latent TGF-beta Binding Protein 1 . Latent TGF-beta Binding Protein 2 . Latent TGF-beta Binding Protein 3 . Latent TGF-beta Binding Protein 4 . Latent TGF beta Binding Protein . Latent TGF beta Binding Protein 1 . Latent TGF beta Binding Protein 2 . Latent TGF beta Binding Protein 3 . Latent TGF beta Binding Protein 4 . Latent TGF beta Binding Proteins . Latent TGF-beta Binding Protein . A family of secreted multidomain proteins that were originally identified by their association with the latent form of TRANSFORMING GROWTH FACTORS. They interact with a variety of EXTRACELLULAR MATRIX PROTEINS and may play a role in the regulation of TGB-beta bioavailability. . 0.55
