TNF-Related Apoptosis-Inducing Ligand. Apo-2 Ligand . Apo-2L Protein . CD253 Antigen . TNF Superfamily, Member 10 . TRAIL Protein . Antigen, CD253 . Apo 2 Ligand . Apo 2L Protein . Apoptosis-Inducing Ligand, TNF-Related . TNF Related Apoptosis Inducing Ligand . Tumor Necrosis Factor Ligand Superfamily Member 10 . A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form. . 0.88
Cytokine TWEAK. Apo3 Ligand . TNF-Related Weak Inducer of Apoptosis . TWEAK Cytokine . Tumor Necrosis Factor Ligand Superfamily Member 12 . Cytokine, TWEAK . Ligand, Apo3 . TNF Related Weak Inducer of Apoptosis . TWEAK, Cytokine . A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION. . 0.60
