Tumor Necrosis Factor-alpha. Cachectin-Tumor Necrosis Factor . TNF Superfamily, Member 2 . TNFalpha . Tumor Necrosis Factor . Cachectin Tumor Necrosis Factor . Tumor Necrosis Factor alpha . Cachectin . TNF-alpha . Tumor Necrosis Factor Ligand Superfamily Member 2 . Tumor Necrosis Factor . Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. . 1.00
Receptors, Tumor Necrosis Factor, Type I. CD 120a Antigen . CD120a Antigen . TNFR p60 . TNFR-I . TNFR1 . TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) . TNFRSF1A Receptor . Tumor Necrosis Factor Receptor 1A . Tumor Necrosis Factor Receptor Type 1 . 120a Antigen, CD . Antigen, CD 120a . Antigen, CD120a . Receptor, TNFRSF1A . Antigens, CD120a . CD120a Antigens . Receptors, Tumor Necrosis Factor, Member 1A . Tumor Necrosis Factor Receptor Superfamily, Member 1A . Tumor Necrosis Factor Receptor Type I . A tumor necrosis factor receptor subtype that has specificity for TUMOR NECROSIS FACTOR ALPHA and LYMPHOTOXIN ALPHA. It is constitutively expressed in most tissues and is a key mediator of tumor necrosis factor signaling in the vast majority of cells. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM. . 0.57
ADAM17 Protein. ADAM-17 . ADAM-17 Protein . CD156b Antigen . Disintegrin and Metalloproteinase Domain-Containing Protein 17 . TACA (Enzyme) . TACE (Enzyme) . TNF-alpha Convertase . TNF-alpha Converting Enzyme . Tumor Necrosis Factor Alpha Convertase . Tumor Necrosis Factor-alpha Convertase . Tumor Necrosis Factor-alpha Converting Enzyme . ADAM 17 Protein . Antigen, CD156b . Convertase, TNF-alpha . Disintegrin and Metalloproteinase Domain Containing Protein 17 . TNF alpha Convertase . TNF alpha Converting Enzyme . Tumor Necrosis Factor alpha Converting Enzyme . A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS. . 0.55
Lymphotoxin-alpha. Lymphotoxin . Lymphotoxin-alpha3 . Soluble Lymphotoxin-alpha . alpha-Lymphotoxin . Lymphotoxin alpha . Lymphotoxin alpha3 . Lymphotoxin-alpha, Soluble . Soluble Lymphotoxin alpha . Tumor Necrosis Factor beta . alpha Lymphotoxin . TNF Superfamily, Member 1 . TNF-beta . Tumor Necrosis Factor-beta . Tumor Necrosis Factor Ligand Superfamily Member 1 . A tumor necrosis factor family member that is released by activated LYMPHOCYTES. Soluble lymphotoxin is specific for TUMOR NECROSIS FACTOR RECEPTOR TYPE I; TUMOR NECROSIS FACTOR RECEPTOR TYPE II; and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14. Lymphotoxin-alpha can form a membrane-bound heterodimer with LYMPHOTOXIN-BETA that has specificity for the LYMPHOTOXIN BETA RECEPTOR. . 0.54
Tumor Necrosis Factor alpha-Induced Protein 3. TNFAIP3 Protein . Zinc Finger Protein A20 . Tumor Necrosis Factor alpha Induced Protein 3 . A UBIQUITIN editing enzyme that functions as both a ubiquitin ligase and deubiquitinase. It contains several ZINC FINGERS and functions in the immune response and INFLAMMATION by modulating signals from TNF-ALPHA; IL1-BETA; or pathogens via TOLL-LIKE RECEPTORS to terminate NF-KAPPA B activity. . 0.51
