serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.455 Hydrocarbons .
D02.455.426 Hydrocarbons, Cyclic .
D02.455.426.559 Hydrocarbons, Aromatic .
D02.455.426.559.847 Polycyclic Aromatic Hydrocarbons .
D02.455.426.559.847.638 Naphthalenes .
D02.455.426.559.847.638.960 Tetrahydronaphthalenes .
D02.455.426.559.847.638.960.675 Podophyllotoxin .
D02.455.426.559.847.638.960.675.250 Etoposide .
D03 Heterocyclic Compounds .
D03.132 Alkaloids .
D03.132.151 Camptothecin .
D03.132.151.850 Topotecan .
D04 Polycyclic Compounds .
D04.615 Polycyclic Aromatic Hydrocarbons .
D04.615.638 Naphthalenes .
D04.615.638.960 Tetrahydronaphthalenes .
D04.615.638.960.675 Podophyllotoxin .
D04.615.638.960.675.250 Etoposide .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.399 Isomerases .
D08.811.399.403 DNA Topoisomerases .
D08.811.399.403.741 DNA Topoisomerases, Type II .
D08.811.399.403.741.224 DNA Topoisomerase IV .
D09 Carbohydrates .
D09.408 Glycosides .
D09.408.348 Glucosides .
D09.408.348.275 Etoposide .
D12 Amino Acids, Peptides, and Proteins .
D12.776 Proteins .
D12.776.097 Bacterial Proteins .
D12.776.097.256 DNA Topoisomerase IV .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
DNA Topoisomerase IV .
Topo IV .
Topoisomerase IV .
Topoisomerase IV Subunit A .
Topoisomerase IV Subunit B .
parC Gene Product .
parC Gene Product, Topo IV .
parE Gene Product .
parE Gene Product, Topo IV .
Topoisomerase IV, DNA .
parC Protein .
parE Protein .
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Topoisomerase IV binds to DNA as a heterotetramer consisting 2 parC and 2 parE subunits. Topoisomerase IV is a decatenating enzyme that resolves interlinked daughter chromosomes following DNA replication. .
1.00
61021
 
Etoposide .
Celltop .
Eposide .
Eposin .
Eto-GRY .
Etomedac .
Etopos .
Etoposide Pierre Fabre .
Etoposide Teva .
Etoposide, (5S)-Isomer .
Etoposide, (5a alpha)-Isomer .
Etoposide, (5a alpha,9 alpha)-Isomer .
Etoposide, alpha-D-Glucopyranosyl Isomer .
Etoposido Ferrer Farma .
Exitop .
Lastet .
NSC-141540 .
Onkoposid .
Riboposid .
Toposar .
VP 16-213 .
VP-16 .
Vepesid .
Vépéside-Sandoz .
Eto GRY .
Etoposide, alpha D Glucopyranosyl Isomer .
NSC 141540 .
NSC141540 .
Teva, Etoposide .
VP 16 .
VP 16 213 .
VP 16213 .
VP16 3939 .
Vépéside Sandoz .
alpha-D-Glucopyranosyl Isomer Etoposide .
Demethyl Epipodophyllotoxin Ethylidine Glucoside .
VP 16-213 .
VP-16 .
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. .
0.56
5815602
 
Topotecan .
9-Dimethylaminomethyl-10-hydroxycamptothecin .
Hycamtamine .
Hycamtin .
NSC-609699 .
Nogitecan Hydrochloride .
SK&F-104864-A .
SKF-104864-A .
Topotecan Hydrochloride .
Topotecan Monohydrochloride, (S)-Isomer .
9 Dimethylaminomethyl 10 hydroxycamptothecin .
Hydrochloride, Nogitecan .
Hydrochloride, Topotecan .
NSC 609699 .
NSC609699 .
SK&F 104864 A .
SK&F104864A .
SKF 104864 A .
SKF104864A .
An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I. .
0.52
51977