serw-MX  [xml]  

 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.464 Ligases .
D08.811.464.938 Ubiquitin-Protein Ligase Complexes .
D08.811.464.938.750 Ubiquitin-Protein Ligases .
 Synonyms & Historicals
Ubiquitin-Protein Ligases .
E3 Ligase .
E3 Ubiquitin Ligase .
Ubiquitin Ligase E3 .
Ubiquitin-Protein Ligase E3 .
Ligase E3, Ubiquitin .
Ligase E3, Ubiquitin-Protein .
Ligase, E3 .
Ligase, E3 Ubiquitin .
Ligase, Ubiquitin-Protein .
Ligases, Ubiquitin-Protein .
Ubiquitin Ligase, E3 .
Ubiquitin Protein Ligase .
Ubiquitin Protein Ligase E3 .
Ubiquitin Protein Ligases .
Ubiquitin-Protein Ligase .
Ubiquitin Ligase E3 .
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes. .
Ubiquitin-Protein Ligase Complexes .
Complexes, Ubiquitin-Protein Ligase .
Ligase Complexes, Ubiquitin-Protein .
Ubiquitin Protein Ligase Complexes .
Complexes of enzymes that catalyze the covalent attachment of UBIQUITIN to other proteins by forming a peptide bond between the C-terminal GLYCINE of UBIQUITIN and the alpha-amino groups of LYSINE residues in the protein. The complexes play an important role in mediating the selective-degradation of short-lived and abnormal proteins. The complex of enzymes can be broken down into three components that involve activation of ubiquitin (UBIQUITIN-ACTIVATING ENZYMES), conjugation of ubiquitin to the ligase complex (UBIQUITIN-CONJUGATING ENZYMES), and ligation of ubiquitin to the substrate protein (UBIQUITIN-PROTEIN LIGASES). .