serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.092 Amines .
D02.092.831 Propylamines .
D02.092.831.845 Tranylcypromine .
D02.455 Hydrocarbons .
D02.455.426 Hydrocarbons, Cyclic .
D02.455.426.559 Hydrocarbons, Aromatic .
D02.455.426.559.389 Benzene Derivatives .
D02.455.426.559.389.657 Phenols .
D02.455.426.559.389.657.410 Hydroxybenzoates .
D02.455.426.559.389.657.410.595 Salicylates .
D02.455.426.559.389.657.410.595.176 Aspirin .
D02.455.426.559.389.657.410.595.176.500 Aspirin, Dipyridamole Drug Combination .
D02.455.426.559.847 Polycyclic Aromatic Hydrocarbons .
D02.455.426.559.847.562 Naphthacenes .
D02.455.426.559.847.562.050 Anthracyclines .
D02.455.426.559.847.562.050.200 Daunorubicin .
D02.455.426.559.847.562.050.200.650 Nogalamycin .
D02.540 Lactones .
D02.540.576 Polyketides .
D02.540.576.500 Macrolides .
D02.540.576.500.992 Erythromycin .
D02.540.576.500.992.100 Clarithromycin .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.742 Pyrimidines .
D03.383.742.175 Dipyridamole .
D03.383.742.175.500 Aspirin, Dipyridamole Drug Combination .
D03.633 Heterocyclic Compounds, Fused-Ring .
D03.633.100 Heterocyclic Compounds, 2-Ring .
D03.633.100.759 Purines .
D03.633.100.759.758 Purinones .
D03.633.100.759.758.399 Hypoxanthines .
D03.633.100.759.758.399.454 Guanine .
D03.633.100.759.758.399.454.650 Pemetrexed .
D03.633.300 Heterocyclic Compounds, 3-Ring .
D03.633.300.200 Dactinomycin .
D04 Polycyclic Compounds .
D04.345 Macrocyclic Compounds .
D04.345.566 Peptides, Cyclic .
D04.345.566.252 Dactinomycin .
D04.615 Polycyclic Aromatic Hydrocarbons .
D04.615.562 Naphthacenes .
D04.615.562.050 Anthracyclines .
D04.615.562.050.200 Daunorubicin .
D04.615.562.050.200.650 Nogalamycin .
D09 Carbohydrates .
D09.408 Glycosides .
D09.408.051 Aminoglycosides .
D09.408.051.059 Anthracyclines .
D09.408.051.059.200 Daunorubicin .
D09.408.051.059.200.650 Nogalamycin .
D12 Amino Acids, Peptides, and Proteins .
D12.125 Amino Acids .
D12.125.067 Amino Acids, Acidic .
D12.125.067.625 Glutamates .
D12.125.067.625.525 Pemetrexed .
D12.125.119 Amino Acids, Dicarboxylic .
D12.125.119.409 Glutamates .
D12.125.119.409.525 Pemetrexed .
D12.644 Peptides .
D12.644.641 Peptides, Cyclic .
D12.644.641.252 Dactinomycin .
D13 Nucleic Acids, Nucleotides, and Nucleosides .
D13.444 Nucleic Acids .
D13.444.308 DNA 12232 .
D13.444.308.130 DNA, A-Form .
D26 Pharmaceutical Preparations .
D26.310 Drug Combinations .
D26.310.125 Aspirin, Dipyridamole Drug Combination .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.570 Molecular Structure .
G02.111.570.820 Molecular Conformation .
G02.111.570.820.486 Nucleic Acid Conformation .
G02.111.570.820.486.128 DNA, A-Form .
G05 Genetic Phenomena .
G05.360 Genetic Structures .
G05.360.580 Nucleic Acid Conformation .
G05.360.580.114 DNA, A-Form .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Dactinomycin .
Cosmegen .
Cosmegen Lyovac .
Lyovac-Cosmegen .
Lyovac Cosmegen .
Lyovac, Cosmegen .
LyovacCosmegen .
Actinomycin D .
Meractinomycin .
Actinomycin .
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015) .
1.00
5517436
 
Nogalamycin .
U-15167 .
U 15167 .
U15167 .
An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA. .
0.36
0224
 
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .
0.33
409137
 
Aspirin, Dipyridamole Drug Combination .
Aggrenox .
Asasantin .
Asasantin Retard .
Aspirin-Dipyridamole Drug Combination .
Extended-Release Dipyridamole-Aspirin .
TX 3301 .
TX-3301 .
3301, TX .
Aspirin Dipyridamole Drug Combination .
Combination, Aspirin-Dipyridamole Drug .
Dipyridamole-Aspirin, Extended-Release .
Drug Combination, Aspirin-Dipyridamole .
Extended Release Dipyridamole Aspirin .
Retard, Asasantin .
A drug combination of aspirin and dipyridamole that functions as a PLATELET AGGREGATION INHIBITOR, used to prevent THROMBOSIS and STROKE in TRANSIENT ISCHEMIC ATTACK patients. .
0.33
064
 
Pemetrexed .
Alimta .
LY 231,514 .
LY 231514 .
LY-231,514 .
LY-231514 .
LY231514 .
MTA 32111 .
N-(4-(2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2,3-d)pyrimdin-5-yl)ethyl)benzoyl)glutamic acid .
Pemetrexed Disodium .
231,514, LY .
231514, LY .
Disodium, Pemetrexed .
A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE. .
0.32
31655
 
Tranylcypromine .
Jatrosom .
Parnate .
Transamine .
Tranylcypromine Sulfate .
trans-2-Phenylcyclopropylamine .
Sulfate, Tranylcypromine .
trans 2 Phenylcyclopropylamine .
A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311) .
0.32
141451
 
DNA, A-Form .
A-DNA .
A-Form DNA .
DNA, A Form .
An isoform of DNA that occurs in an environment rich in SODIUM and POTASSIUM ions. It is a right-handed helix with 11 base pairs per turn, a pitch of 0.256 nm per base pair and a helical diameter of 2.3 nm. .
0.31
182
 
Clarithromycin .
6-O-Methylerythromycin .
A-56268 .
Biaxin .
TE-031 .
A 56268 .
A56268 .
TE 031 .
TE031 .
A semisynthetic macrolide antibiotic derived from ERYTHROMYCIN that is active against a variety of microorganisms. It can inhibit PROTEIN SYNTHESIS in BACTERIA by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation. .
0.31
1645705