serw-MX  [xml]  
 


    
 DeCS Categories

D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.913 Transferases .
D08.811.913.696 Phosphotransferases .
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) .
D08.811.913.696.620.682 Protein Kinases .
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400 Receptor Protein-Tyrosine Kinases .
D08.811.913.696.620.682.725.400.005 Discoidin Domain Receptors .
D08.811.913.696.620.682.725.400.005.500 Discoidin Domain Receptor 1 .
D12 Amino Acids, Peptides, and Proteins .
D12.644 Peptides .
D12.644.276 Intercellular Signaling Peptides and Proteins .
D12.644.276.200 CCN Intercellular Signaling Proteins .
D12.644.276.200.500 Nephroblastoma Overexpressed Protein .
D12.644.276.374 Cytokines .
D12.644.276.374.410 Hematopoietic Cell Growth Factors .
D12.644.276.374.410.800 Stem Cell Factor .
D12.644.276.954 TGF-beta Superfamily Proteins .
D12.644.276.954.200 Bone Morphogenetic Proteins .
D12.776 Proteins .
D12.776.467 Intercellular Signaling Peptides and Proteins .
D12.776.467.200 CCN Intercellular Signaling Proteins .
D12.776.467.200.500 Nephroblastoma Overexpressed Protein .
D12.776.467.374 Cytokines .
D12.776.467.374.410 Hematopoietic Cell Growth Factors .
D12.776.467.374.410.800 Stem Cell Factor .
D12.776.467.942 TGF-beta Superfamily Proteins .
D12.776.467.942.200 Bone Morphogenetic Proteins .
D12.776.543 Membrane Proteins .
D12.776.543.750 Receptors, Cell Surface .
D12.776.543.750.630 Receptor Protein-Tyrosine Kinases .
D12.776.543.750.630.005 Discoidin Domain Receptors .
D12.776.543.750.630.005.500 Discoidin Domain Receptor 1 .
D12.776.543.750.685 Receptors, Collagen .
D12.776.543.750.685.050 Discoidin Domain Receptors .
D12.776.543.750.685.050.500 Discoidin Domain Receptor 1 .
D12.776.543.750.705 Receptors, Immunologic .
D12.776.543.750.705.880 Receptors, Mitogen .
D12.776.543.750.705.880.300 Discoidin Domain Receptors .
D12.776.543.750.705.880.300.500 Discoidin Domain Receptor 1 .
D12.776.543.750.750 Receptors, Peptide .
D12.776.543.750.750.555 Receptors, Neuropeptide .
D12.776.543.750.750.555.770 Receptors, Somatotropin .
D12.776.543.750.750.660 Receptors, Pituitary Hormone .
D12.776.543.750.750.660.750 Receptors, Somatotropin .
D12.776.860 Scleroproteins .
D12.776.860.300 Extracellular Matrix Proteins .
D12.776.860.300.200 CCN Intercellular Signaling Proteins .
D12.776.860.300.200.500 Nephroblastoma Overexpressed Protein .
D23 Biological Factors .
D23.101 Biomarkers .
D23.101.140 Biomarkers, Tumor .
D23.101.140.450 Nephroblastoma Overexpressed Protein .
D23.529 Intercellular Signaling Peptides and Proteins .
D23.529.237 CCN Intercellular Signaling Proteins .
D23.529.237.600 Nephroblastoma Overexpressed Protein .
D23.529.374 Cytokines .
D23.529.374.410 Hematopoietic Cell Growth Factors .
D23.529.374.410.800 Stem Cell Factor .
D23.529.942 TGF-beta Superfamily Proteins .
D23.529.942.200 Bone Morphogenetic Proteins .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.570 Molecular Structure .
G02.111.570.820 Molecular Conformation .
G02.111.570.820.709 Protein Conformation .
G02.111.570.820.709.275 Protein Structural Elements .
G02.111.570.820.709.275.750 Protein Domains .
G02.111.570.820.709.275.750.469 Pleckstrin Homology Domains .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
CCN Intercellular Signaling Proteins .
CCN Family Proteins .
CYR61 CTGF NOV Matricellular Proteins .
Matricellular CCN Proteins .
A family of secreted proteins found associated with the EXTRACELLULAR MATRIX and cell surface receptors. They are believed to play a role in modulating the effects of a variety of GROWTH FACTORS and PROTEASES at the cell membrane extracellular matrix. The CCN protein family is named after three protypical members; CYSTEINE-RICH PROTEIN 61; CONNECTIVE TISSUE GROWTH FACTOR; and NEPHROBLASTOMA OVEREXPRESSED PROTEIN. .
1.00
0320
 
Nephroblastoma Overexpressed Protein .
CCN3 Protein .
IGFBP9 Protein .
NOVH Protein .
Nephroblastoma Overexpressed Gene Product .
A CCN protein family member found at high levels in NEPHROBLASTOMA cells. It is found both intracellularly and in the EXTRACELLULAR MATRIX and may play a role in the regulation of CELL PROLIFERATION and EXTRACELLULAR MATRIX synthesis. .
0.53
0182
 
Extracellular Matrix Proteins .
Matrix Proteins, Extracellular .
Proteins, Extracellular Matrix .
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ). .
0.46
6017783
 
Pleckstrin Homology Domains .
PH Domain .
PH Domains .
Pleckstrin Homology Domain .
Domain, PH .
Domain, Pleckstrin Homology .
Domains, PH .
Domains, Pleckstrin Homology .
Homology Domain, Pleckstrin .
Homology Domains, Pleckstrin .
Protein domains of approximately 120 amino acids that form two perpendicular anti-parallel beta sheets connected by a loop of variable length and a C-terminal amphipathic helix. PH domains occur in many INTRACELLULAR SIGNALING PROTEINS and CYTOSKELETAL PROTEINS where they bind PHOSPHATIDYLINOSITOLS within the CELL MEMBRANE and INTRACELLULAR MEMBRANES, as well as proteins that include the Betagamma-subunits of HETEROTRIMERIC GTP-BINDING PROTEINS, and PROTEIN KINASE C. These interactions allow the targeting of proteins to different cellular compartments and SIGNAL TRANSDUCTION PATHWAYS. .
0.42
023
 
Stem Cell Factor .
kit Ligand .
c kit Ligand .
c-kit Ligand .
Mast Cell Growth Factor .
Steel Factor .
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS. .
0.41
144124
 
Receptors, Somatotropin .
Growth Hormone Receptor .
Receptor, Growth Hormone .
Receptors, Somatomammotropin .
Somatomammotropin Receptor .
Somatotropin Receptor .
Hormone Receptor, Growth .
Hormone Receptors, Growth .
Growth Hormone Receptors .
Somatomammotropin Receptors .
Somatotropin Receptors .
Receptors, Growth Hormone .
Cell surface proteins that bind GROWTH HORMONE with high affinity and trigger intracellular changes influencing the behavior of cells. Activation of growth hormone receptors regulates amino acid transport through cell membranes, RNA translation to protein, DNA transcription, and protein and amino acid catabolism in many cell types. Many of these effects are mediated indirectly through stimulation of the release of somatomedins. .
0.40
262948
 
Discoidin Domain Receptor 1 .
CD167 Antigen .
DDR1 Protein .
Discoidin Domain Receptor Family, Member 1 Protein .
Discoidin Domain Receptor Tyrosine Kinase 1 .
Antigen, CD167 .
Protein, DDR1 .
A discoidin domain receptor for FIBRILLAR COLLAGEN that functions in a variety of cellular processes. For example, it regulates cell attachment to the EXTRACELLULAR MATRIX, remodeling of the extracellular matrix, CELL MIGRATION; CELL DIFFERENTIATION; CELL PROLIFERATION; and CELL SURVIVAL. .
0.39
0154
 
Bone Morphogenetic Proteins .
Bone Morphogenetic Protein .
Morphogenetic Protein, Bone .
Morphogenetic Proteins, Bone .
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins. .
0.39
10111374