serw-MX  [xml]  

 DeCS Categories

D02 Organic Chemicals .
D02.455 Hydrocarbons .
D02.455.326 Hydrocarbons, Acyclic .
D02.455.326.397 Alkynes .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.074 DNA Repair Enzymes .
D08.811.074.062 AlkB Enzymes .
D08.811.682 Oxidoreductases .
D08.811.682.690 Oxygenases .
D08.811.682.690.416 Dioxygenases .
D08.811.682.690.416.139 AlkB Enzymes .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
G02 Chemical Phenomena .
G02.111 Biochemical Phenomena .
G02.111.035 Alkylation .
G02.111.188 Dealkylation .
G02.607 Organic Chemistry Phenomena .
G02.607.094 Alkylation .
G02.607.141 Dealkylation .
G03 Metabolism .
G03.059 Alkylation .
G03.219 Dealkylation .
 Synonyms & Historicals
Alkylation .
Alkylations .
The covalent bonding of an alkyl group to an organic compound. It can occur by a simple addition reaction or by substitution of another functional group. .
Alkylating Agents .
Alkylators .
Agents, Alkylating .
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. .
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .
AlkB Enzymes .
AlkB Homologs .
Alkylated DNA Repair Protein AlkB Homologs .
Alkylation Repair Homolog Proteins .
Alkylation Repair Homologs .
Enzymes, AlkB .
A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE). .
Dealkylation .
Dealkylations .
The removing of alkyl groups from a compound. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) .
Alkynes .
Acetylenes .
Acetylenic Compounds .
Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2. .