serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.033 Alcohols .
D02.033.800 Sugar Alcohols .
D02.033.800.609 Mannitol .
D02.033.800.609.500 Mitobronitol .
D02.455 Hydrocarbons .
D02.455.326 Hydrocarbons, Acyclic .
D02.455.326.146 Alkanes .
D02.455.326.146.100 Alkanesulfonic Acids .
D02.455.326.146.100.050 Alkanesulfonates .
D02.455.326.146.100.050.500 Mesylates .
D02.455.326.146.100.050.500.300 Ethyl Methanesulfonate .
D02.455.326.146.100.050.500.500 Methyl Methanesulfonate .
D02.654 Nitroso Compounds .
D02.654.692 Nitrosourea Compounds .
D02.654.692.768 Streptozocin .
D02.886 Sulfur Compounds .
D02.886.645 Sulfur Acids .
D02.886.645.600 Sulfonic Acids .
D02.886.645.600.055 Alkanesulfonic Acids .
D02.886.645.600.055.050 Alkanesulfonates .
D02.886.645.600.055.050.510 Mesylates .
D02.886.645.600.055.050.510.300 Ethyl Methanesulfonate .
D02.886.645.600.055.050.510.500 Methyl Methanesulfonate .
D02.948 Urea 11093 .
D02.948.594 Nitrosourea Compounds .
D02.948.594.768 Streptozocin .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.606 Piperazines .
D03.383.606.773 Pipobroman .
D09 Carbohydrates .
D09.408 Glycosides .
D09.408.051 Aminoglycosides .
D09.408.051.900 Streptozocin .
D09.853 Sugar Alcohols .
D09.853.609 Mannitol .
D09.853.609.500 Mitobronitol .
D27 Chemical Actions and Uses .
D27.505 Pharmacologic Actions .
D27.505.519 Molecular Mechanisms of Pharmacological Action .
D27.505.519.124 Alkylating Agents .
D27.505.519.124.035 Antineoplastic Agents, Alkylating .
D27.505.954 Therapeutic Uses .
D27.505.954.248 Antineoplastic Agents .
D27.505.954.248.150 Antineoplastic Agents, Alkylating .
D27.888 Toxic Actions .
D27.888.569 Noxae .
D27.888.569.035 Alkylating Agents .
D27.888.569.035.035 Antineoplastic Agents, Alkylating .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
Ethyl Methanesulfonate .
Ethyl Mesilate .
Ethyl Mesylate .
Ethylmesilate .
Ethylmesylate .
Mesilate, Ethyl .
Mesylate, Ethyl .
Methanesulfonate, Ethyl .
Sulfonate, Ethylmethane .
Ethylmethane Sulfonate .
An antineoplastic agent with alkylating properties. It also acts as a mutagen by damaging DNA and is used experimentally for that effect. .
1.00
71879
 
Methyl Methanesulfonate .
Dimethylsulfonate .
Mesilate, Methyl .
Methyl Mesylate .
Methyl Methylenesulfonate .
Methylmesilate .
Mesylate, Methyl .
Methanesulfonate, Methyl .
Methyl Mesilate .
Methylmethane Sulfonate .
An alkylating agent in cancer therapy that may also act as a mutagen by interfering with and causing damage to DNA. .
0.65
 
Pipobroman .
Vercyte .
An antineoplastic agent that acts by alkylation. .
0.46
080
 
Alkylating Agents .
Alkylators .
Agents, Alkylating .
Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. .
0.45
406645
 
Mitobronitol .
Myelobromol .
NSC-94,100 .
NSC-94100 .
NSC 94,100 .
NSC 94100 .
NSC94,100 .
NSC94100 .
Dibromomannitol .
Brominated analog of MANNITOL which is an antineoplastic agent appearing to act as an alkylating agent. .
0.44
050
 
Streptozocin .
2-Deoxy-2-((methylnitrosoamino)carbonyl)amino-D-glucose .
Streptozotocine .
Zanosar .
Streptozotocin .
An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. .
0.43
 
Antineoplastic Agents, Alkylating .
Alkylating Antineoplastic Agents .
Alkylating Antineoplastic Drugs .
Alkylating Antineoplastics .
Alkylating Drugs, Antineoplastic .
Antineoplastic Alkylating Agents .
Antineoplastic Drugs, Alkylating .
Antineoplastics, Alkylating .
Antineoplastic Alkylating Drugs .
Drugs, Antineoplastic Alkylating .
Alkylating Agents, Antineoplastic .
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026) .
0.42