serw-MX  [xml]  
 


    
 DeCS Categories

D02 Organic Chemicals .
D02.065 Amides .
D02.065.589 Lactams .
D02.065.589.099 beta-Lactams .
D02.065.589.099.500 Monobactams .
D02.065.589.099.750 Penicillins .
D02.065.589.099.750.812 Sulbactam .
D02.886 Sulfur Compounds .
D02.886.108 beta-Lactams .
D02.886.108.500 Monobactams .
D02.886.108.750 Penicillins .
D02.886.108.750.812 Sulbactam .
D03 Heterocyclic Compounds .
D03.383 Heterocyclic Compounds, 1-Ring .
D03.383.411 Lactams .
D03.383.411.350 Monobactams .
D03.633 Heterocyclic Compounds, Fused-Ring .
D03.633.100 Heterocyclic Compounds, 2-Ring .
D03.633.100.300 beta-Lactams .
D03.633.100.300.500 Monobactams .
D03.633.100.300.750 Penicillins .
D03.633.100.300.750.812 Sulbactam .
D08 Enzymes and Coenzymes .
D08.811 Enzymes .
D08.811.277 Hydrolases .
D08.811.277.087 Amidohydrolases .
D08.811.277.087.180 beta-Lactamases .
G06 Microbiological Phenomena .
G06.099 Bacterial Physiological Phenomena .
G06.099.225 Drug Resistance, Bacterial .
G06.099.225.500 beta-Lactam Resistance .
G06.225 Drug Resistance, Microbial .
G06.225.347 Drug Resistance, Bacterial .
G06.225.347.500 beta-Lactam Resistance .
G07 Physiological Phenomena .
G07.690 Pharmacological and Toxicological Phenomena .
G07.690.773 Pharmacological Phenomena .
G07.690.773.984 Drug Resistance .
G07.690.773.984.269 Drug Resistance, Microbial .
G07.690.773.984.269.347 Drug Resistance, Bacterial .
G07.690.773.984.269.347.500 beta-Lactam Resistance .
 
 Terms
 Synonyms & Historicals
Documents
LILACS e MDL
 
beta-Lactams .
4-Thia-1-Azabicyclo(3.2.0)Heptanes .
4-Thia-1-Azabicyclo(4.2.0)Octanes .
beta Lactams .
Antibiotics, beta-Lactam .
beta-Lactam Antibiotics .
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria. .
1.00
585858
 
Lactams .
Lactims .
Antibiotics, Lactam .
Cyclic AMIDES formed from aminocarboxylic acids by the elimination of water. Lactims are the enol forms of lactams. .
0.83
1253770
 
beta-Lactam Resistance .
beta-Lactam Resistant .
beta-Lactamase Resistance .
beta-Lactamase Resistant .
Resistance, beta-Lactamase .
Resistant, beta-Lactamase .
beta Lactam Resistance .
beta Lactam Resistant .
beta Lactamase Resistance .
beta Lactamase Resistant .
Nonsusceptibility of bacteria to the action of the beta-lactam antibiotics. Mechanisms responsible for beta-lactam resistance may be degradation of antibiotics by BETA-LACTAMASES, failure of antibiotics to penetrate, or low-affinity binding of antibiotics to targets. .
0.75
1234000
 
Sulbactam .
Bétamaze .
CP-45899 .
Combactam .
Penicillanic Acid Sulfone .
Sulbactam Sodium .
CP 45899 .
CP45899 .
Sodium, Sulbactam .
Sulfone, Penicillanic Acid .
A beta-lactamase inhibitor with very weak antibacterial action. The compound prevents antibiotic destruction of beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. .
0.74
651549
 
Monobactams .
Monobactam Antibiotics .
Monocyclic beta Lactams .
beta Lactams, Monocyclic .
beta-Lactams, Monocyclic .
Monocyclic beta-Lactams .
Antibiotics, Monobactam .
Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized. .
0.68
11301
 
beta-Lactamases .
beta-Lactamase .
beta Lactamase .
beta Lactamases .
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins. .
0.66
40217579